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Comparison the Anti-Oxidant and Anti-Inflammatory Effects of Silymarin and Nano Silymarin on Hyperlipidemic Rats
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R Mohebbati    , MA Momeni-Moghaddam , S Mehrabi , A Abbasnezhad * , M Shokrgozar , M Alishahi , D Salarbashi , SH Abtahi , Z Heydarnia |
| 1.Nursing Research Center, Gonabad University of Medical Sciences, Gonabad, I.R.Iran. , abbasnezhad.abbasali@gmail.com |
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Abstract: (17 Views) |
Background and Objective: Medicinal plants have been used for centuries in the treatment of many diseases such as diabetes, cataracts, cancer, inflammatory diseases and blood lipids. This study aimed to compare the antioxidant and anti-inflammatory effects of silymarin and nanosilymarin in hyperlipidemic rats fed with a high-fat diet (HFD).
Methods: In this experimental study, 35 male rats were divided into 5 groups (n=7) including control, negative control (HFD), HFD and atorvastatin (20 mg/kg) (positive control), HFD and silymarin (100 mg/kg), HFD and Nanosilymarin (100 mg/kg) were divided. Feeding with high-fat diet for 12 weeks induced oxidative stress. Drugs were also gavage for 12 weeks. At the end, blood samples were taken to measure lipid profile, tumor necrosis factor alpha (TNF-α), interleukin 17, malondialdehyde (MDA) and superoxide dismutase (SOD).
Findings: Nanosilymarin was able to significantly reduce the triglyceride level by 93.2 units compared to the negative control (p<0.001), but the reduction of cholesterol and LDL-C by nanosilymarin was not significant. TNF-α in the negative control group was significantly higher than the control by 31 units (p=0.006). The groups receiving atorvastatin, silymarin and nanosilymarin decreased the levels of TNF-α and interleukin 17 significantly compared to the negative control group. The level of MDA in the negative control group increased by 0.8 units compared to the control group (p=0.001), but in the silymarin, nanosilymarin, and atorvastatin groups, compared to the negative control group, it showed a significant decrease of 0.8, 1, and 0.9 units, respectively. gave (p<0.001).
Conclusion: Based on the results, the use of nanosilymarin compared to silymarin in mice treated with a high-fat diet led to a relative decrease in lipid profile, while there were no differences in terms of antioxidant and anti-inflammatory properties.
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| Keywords: Silymarin, Nanoparticle, Oxidative Stress, Inflammation, Hyperlipidemias. |
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Type of Study: Experimental |
Subject:
Physiology
Received: 2024/08/18 | Accepted: 2024/10/12
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