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Comparison of the Antioxidant and Anti-Inflammatory Effects of Silymarin and Nano-Silymarin in Hyperlipidemic Rats
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R Mohebbati    , MA Momeni-Moghaddam , S Mehrabi , A Abbasnezhad * , M Shokrgozar , M Alishahi , D Salarbashi , SH Abtahi , Z Heydarnia |
| 1.Nursing Research Center, Gonabad University of Medical Sciences, Gonabad, I.R.Iran. , abbasnezhad.abbasali@gmail.com |
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Abstract: (383 Views) |
Background and Objective: For centuries, medicinal plants have been used in the treatment of many diseases and hyperlipidemia. The present study was conducted to compare the antioxidant and anti-inflammatory effects of silymarin and nano-silymarin in hyperlipidemic rats receiving a high-fat diet (HFD).
Methods: In this experimental study, 35 male rats were divided into 5 groups of 7, including control, negative control (HFD), HFD and atorvastatin (20 mg/kg) (positive control), HFD and silymarin (100 mg/kg), and HFD and nano-silymarin (100 mg/kg). Receiving a high-fat diet for 12 weeks induced oxidative stress. Drugs were administered through gavage feeding for 12 weeks. Finally, blood samples were taken to measure lipid profile, tumor necrosis factor alpha (TNF-α), interleukin 17, malondialdehyde (MDA), and superoxide dismutase (SOD).
Findings: Nano-silymarin was able to significantly reduce triglyceride levels by 2.93 units compared to the negative control (p<0.001), but the reduction of cholesterol and LDL-C by nano-silymarin was not significant. TNF-α in the negative control group was significantly higher by 31 units compared to the control (p=0.006). TNF-α and interleukin 17 levels were not significantly reduced in the groups receiving atorvastatin, silymarin and nano-silymarin compared to the negative control group. MDA levels in the negative control group increased by 0.8 units compared to the control group (p=0.001), but in the silymarin, nano-silymarin and atorvastatin groups, they showed a significant decrease by 0.8, 1 and 0.9 units compared to the negative control group, respectively (p<0.001).
Conclusion: According to the results of this study, the use of nano-silymarin compared to silymarin in rats receiving a high-fat diet led to a relative reduction in lipid profiles, but there was no difference in terms of antioxidant and anti-inflammatory properties. |
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| Keywords: Silymarin, Nanoparticles, Oxidative Stress, Inflammation, Hyperlipidemia. |
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Full-Text [PDF 390 kb]
(33 Downloads)
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Type of Study: Experimental |
Subject:
Physiology
Received: 2024/08/18 | Accepted: 2024/10/12 | Published: 2025/11/17
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