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Impact of SCN10A Gene Polymorphism on the Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis
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A Salem Milani    , K Jamalvand * , S Mansouri Derakhshan , M Alivand , L Rostamizadeh , V Zand , A Nouroloyouni , T Barati , Z Mirzaei |
| 1.Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, I.R.Iran. , khatere.jamalvand13@gmail.com |
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Abstract: (319 Views) |
Background and Objective: The success rate of inferior alveolar nerve block (IANB) is lower in teeth with symptomatic irreversible pulpitis, and the reported failure rate is variable. Since SCN10A gene polymorphisms can alter the effect of anesthetics on sodium channels, the present study was conducted to investigate the impact of SCN10A gene polymorphisms (rs6801957 and rs6795970), which encode Nav1.8, on the success of inferior alveolar nerve block (IANB) in mandibular molars with symptomatic irreversible pulpitis.
Methods: This cross-sectional study was conducted on 194 patients who required root canal treatment of the first or second mandibular molars due to symptomatic irreversible pulpitis. Root canal treatment began 10 minutes after lip anesthesia, when no response to the cold test or electric pulp test was observed. Saliva samples were collected for DNA extraction, and the polymorphisms were identified using Tetra ARMS PCR. The success to failure ratio of IANB was evaluated for different SCN10A polymorphisms.
Findings: Of the 194 examined patients, 87 (44.8%) were male and 107 (55.2%) were female. The success rate of IANB was significantly higher in women (61.7% vs. 46%, p=0.022). Patient age had no statistically significant effect on the success or failure of IANB. In rs6801957 polymorphism, no significant difference was observed in the success to failure ratio of IANB between genotypes and alleles. However, in the rs6795970 polymorphism, the AA and GG genotypes had significantly higher success to failure ratios (OR=1.398 and 5.182, respectively, p=0.015). Men in both the rs6801957 and rs6795970 genotypes had a lower success rate compared to women (OR=0.66).
Conclusion: The results of the study demonstrated that the rs6795970 polymorphism of the SCN10A gene significantly affects the success of IANB in mandibular molars with symptomatic irreversible pulpitis, and that male patients as well as those with the AG genotype of the rs6795970 polymorphism are at a higher risk of IANB failure. |
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| Keywords: SCN10A, Polymorphism, Inferior Alveolar Nerve, Irreversible Pulpitis, Mandibular Molars. |
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Full-Text [PDF 308 kb]
(47 Downloads)
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Type of Study: Research |
Subject:
Dentistry (Endo)
Received: 2024/11/19 | Accepted: 2025/02/4 | Published: 2026/04/28
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