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Investigating the Protective Effects of Carvacrol on Cholemic Nephropathy in Cholestatic Rats
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SMG Hosseini    , A Ghafarian Behrman , I Salimi Kia , M Mohammadi , F Asadi Dolatabad , H Mohammadi * |
| 3.Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, I.R.Iran. , hamidrezamohammadi65@yahoo.com |
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Abstract: (25 Views) |
Background and Objective: Kidneys are one of the organs that are damaged after cirrhosis. This kidney tissue damage following liver tissue failure is called cholemic nephropathy. Since one of the main mechanisms in causing Cholemic nephropathy is oxidative stress and reducing antioxidant reserves, the purpose of this study is to investigate the protective effect of carvacrol as an antioxidant on Cholemic nephropathy in cholestatic rats.
Methods: This experimental study was conducted on 40 Wistar rats. The rats were divided into 5 groups of 8. Induction of cholestasis was done by occluding the bile ducts. Animals were gavage with different doses of caravocrol (25-50-100 mg/kg). At the end of the period, serum biochemical factors such as creatinine (Cr) and urea nitrogen (BUN) and urinary factors that include glucose (Glucose) and protein (Protein), the amount of reactive oxygen species (ROS), lipid peroxidation (MDA) and also the activity of anti-inflammatory enzymes Oxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were evaluated in cholestatic rats after administration of carvacrol in kidney tissue.
Findings: Serum levels of BUN and Cr in cholestatic rats were (59±2, 0.8) respectively, which were increased compared to control groups (17±2, 0.18) (p=0.002). The serum oxidative stress indices of MAD, ROS in cholestatic rats were (17±1, 154109) respectively, which was significantly higher than the control group (5±1, 37124±11) (p=0.007) and enzyme activity Antioxidants (CAT, SOD, GPx) in cholestatic rats were respectively (200±11, 19±3, 20±1) compared to the control group (600±34, 64±2, 43±1) respectively. There was a significant decrease (p=0.001).
Conclusion: The results of the study showed that the administration of carvacrol can reduce the oxidative stress caused by closing the bile ducts in the kidneys. |
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| Keywords: Oxidative Stress, Bile Duct Ligation, Cholemic Nephropathy, Carvacrol. |
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Type of Study: Experimental |
Subject:
Pharmacology
Received: 2024/06/27 | Accepted: 2024/10/12
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