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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 1, Issue 1 (1-1999) ::
J Babol Univ Med Sci. 1999; Volume 1 Back to browse issues page
Experimental study of the effect of Caffeine on Pentazocine analgesia
A Arzi * , A Dehghani
Abstract:   (10352 Views)
Objective: In this study the effect of caffeine on pentazocine analgesia in rats was assessed by “Tail-immersion test”. Methods: This study was performed by “Tail-immersion test”. Animals were juvenile M-Mari Rats (Male or female) weighing 120-160 gr. Findings: The average control latencies in “Tail-immersion test” were about 1.5-2 sec. The response latencies of rats which had been given caffeine (25, 50, 75 and 100 mg/kg I.P) or propyleneglycol (40%) were not significant comparing to those receiving an injection of the control vehicle over the 2 hours of testing period. Conclusion: The response latencies of pretreated parts with caffeine (100 mg/kg I.P) during 15, 30, 45 and 60 minutes after the injection of (10, 15, 20 and 25 mg/kg S.C) of pentazocine were significantly higher than those of control group. But injection of lower doses of caffeine and pentazocine did not show a significant analgesic effect compared with the control group.
Keywords: Analgesia, Pentazocine, Caffeine, Drug interaction
Full-Text [PDF 944 kb]   (2028 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/05/25 | Published: 2014/05/25


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Arzi A, Dehghani A. Experimental study of the effect of Caffeine on Pentazocine analgesia. J Babol Univ Med Sci 1999; 1 (1) :7-11
URL: http://jbums.org/article-1-2962-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 1, Issue 1 (1-1999) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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