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Experimental study of the effect of Caffeine on Pentazocine analgesia
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A Arzi *   , A Dehghani |
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Abstract: (11535 Views) |
| Objective: In this study the effect of caffeine on pentazocine analgesia in rats was assessed by “Tail-immersion test”. Methods: This study was performed by “Tail-immersion test”. Animals were juvenile M-Mari Rats (Male or female) weighing 120-160 gr. Findings: The average control latencies in “Tail-immersion test” were about 1.5-2 sec. The response latencies of rats which had been given caffeine (25, 50, 75 and 100 mg/kg I.P) or propyleneglycol (40%) were not significant comparing to those receiving an injection of the control vehicle over the 2 hours of testing period. Conclusion: The response latencies of pretreated parts with caffeine (100 mg/kg I.P) during 15, 30, 45 and 60 minutes after the injection of (10, 15, 20 and 25 mg/kg S.C) of pentazocine were significantly higher than those of control group. But injection of lower doses of caffeine and pentazocine did not show a significant analgesic effect compared with the control group. |
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| Keywords: Analgesia, Pentazocine, Caffeine, Drug interaction |
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Full-Text [PDF 944 kb]
(2453 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/05/25 | Published: 2014/05/25
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