|
Thyroglobulin Cut-Off Value Predicts Distant Metastases in Differentiated Thyroid Carcinoma
|
A Gholami    , N Rezaei , H Gholinia , SH Mousavie Anijdan * |
| 4.Department of Radiation Technology, Faculty of Allied Medical Sciences, Babol University of Medical Sciences, Babol, I.R.Iran. , shmosavia@gmail.com |
|
|
Abstract: (243 Views) |
Background and Objective: Serum thyroglobulin (Tg) is a biochemical marker for the diagnosis of persistent or recurrent differentiated thyroid carcinoma (DTC) after total thyroidectomy. The purpose of this study is to determine the thyroglobulin cut-off value in distant metastases in patients with DTC.
Methods: In this retrospective study, patients with DTC who were treated with radioactive iodine after total thyroidectomy from 2006 to 2023 were examined in the nuclear medicine department. For follow-up of high-risk patients with distant metastases, only patients with postoperative stimulated thyroglobulin (ps-Tg) above 10 ng/ml with negative anti-thyroglobulin antibodies were selected.
Findings: A total of 424 patients were included in the study, of which 335 (79%) were women and 89 (21%) were men. Based on the location of involvement, metastases were seen in lungs, bones and brain in the order of prevalence. By ROC analysis, the optimal ps-Tg cut-off value 41.5 ng/ml predicted the presence of distant metastases with the highest sensitivity (90%) and specificity (88.5%) with the area under the curve of 0.959.
Conclusion: The serum level of Ps-Tg can be considered as a suitable and reliable indicator in showing the recurrence risk and distant metastasis. This value may be the only indicator to be used for this purpose.
|
|
| Keywords: Differentiated Thyroid Carcinoma, Radioiodine Remnant Ablation, Postoperative Stimulated Thyroglobulin, Distant Metastasis. |
|
|
|
Type of Study: Cross Sectional |
Subject:
Nuclear Medicine
Received: 2024/07/7 | Accepted: 2024/10/12
|
|
|
|
|
|
|
| Send email to the article author |
|
|
