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Determining A Thyroglobulin Cut-Off Value to Predict Distant Metastases in Differentiated Thyroid Carcinoma
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A Gholami    , N Rezaei , H Gholinia , SH Mousavie Anijdan * |
| 4.Department of Radiation Technology, Faculty of Allied Medical Sciences, Babol University of Medical Sciences, Babol, I.R.Iran. , shmosavia@gmail.com |
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Abstract: (449 Views) |
Background and Objective: Serum thyroglobulin (Tg) is a biochemical marker for the diagnosis of persistent or recurrent differentiated thyroid carcinoma (DTC) after total thyroidectomy. The purpose of this study is to determine the thyroglobulin cut-off value in distant metastases in patients with DTC.
Methods: Of patients with DTC who referred to the nuclear medicine department for radioactive iodine therapy after total thyroidectomy from 2008 to 2023, 424 patients were enrolled to this cross-sectional study. For follow-up of high-risk patients with distant metastases, only patients with postoperative stimulated thyroglobulin (ps-Tg) above 10 ng/ml with negative anti-thyroglobulin antibodies were selected.
Findings: Of these 424 patients, 335 (79%) were female and 89 (21%) were male. Based on the location of involvement, metastases were seen in lungs, bones and brain in the order of prevalence. According to ROC analysis, the optimal ps-Tg cut-off value 41.5 ng/ml predicted the presence of distant metastases with the highest sensitivity (90%) and specificity (88.5%) with an area under the curve of 0.959.
Conclusion: The results demonstrated that the serum level of Ps-Tg can be considered as a suitable and reliable indicator in showing the recurrence risk and distant metastasis. This value may be the only indicator to be used for this purpose. |
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| Keywords: Differentiated Thyroid Carcinoma, Radioactive Iodine Therapy, Stimulated Serum Thyroglobulin Level, Distant Metastasis. |
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Full-Text [PDF 285 kb]
(41 Downloads)
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Type of Study: Cross Sectional |
Subject:
Nuclear Medicine
Received: 2024/07/7 | Accepted: 2024/10/12 | Published: 2025/08/12
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