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Comparison of Serum Selenium Levels in Children with and without Subclinical Hypothyroidism
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H Ghaffari Hamedani    , H Parsian , H Shirafkan , M Pournasrollah , A Mousapour , Z Panahivand , M Alijanpour * |
| 6.Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , m.alijanpour@yahoo.com |
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Abstract: (182 Views) |
Background and Objective: Subclinical hypothyroidism is a condition without obvious symptoms, with a risk of developing into overt hypothyroidism of 2-5% per year. Given that the relationship between serum selenium concentration and thyroid function is unclear, the aim of this study was to compare serum selenium levels in children with and without subclinical hypothyroidism.
Methods: This case-control study was conducted on 103 children aged 3 to 18 who referred to Amirkola Children's Hospital, Babol, during 2022-3. The case group had normal T4 level for age and TSH higher than the normal range of 5.5 mlU/L and the control group was characterized by normal growth and thyroid tests and physical examination. T4 and TSH levels were measured by Enzyme-linked immunosorbent and selenium levels were measured by atomic absorption spectrometry.
Findings: The demographic data of two groups including age, gender, body mass index, age group, mother's education, father's education and place of residence had no significant statistical difference.103 children (53 and 50 children with and without subclinical hypothyroidism, respectively) were included in the study. The mean serum selenium was 74.9±26.54 ϻg/l (76.48 in the case group and 73.27 in the control group, respectively) and no significant difference was found between the groups (MD=3.21, CI: 0.34-3.48, p=0.883). The selenium level of children with TSH less than 5.5 compared to children with TSH above 5.5 was higher by 4.33 units, but this difference was not significant (OR=1.01, CI: 0.43-2.34, p=0.982).
Conclusion: In the present study, there was no significant difference in serum selenium concentration in children with and without subclinical hypothyroidism. |
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| Keywords: Hypothyroidism, Selenium, Children. |
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Type of Study: Case-Control |
Subject:
Children
Received: 2024/06/11 | Accepted: 2024/10/12
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