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Comparison of Serum Selenium Levels in Children with and without Subclinical Hypothyroidism
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H Ghaffari Hamedani    , H Parsian , H Shirafkan , M Pournasrollah , A Mousapour , Z Panahivand , M Alijanpour * |
| 6.Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , m.alijanpour@yahoo.com |
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Abstract: (401 Views) |
Background and Objective: Subclinical hypothyroidism is a condition without obvious symptoms, with a risk of developing into overt hypothyroidism of 2-5% per year. Given that the relationship between serum selenium concentration and thyroid function is unclear, the present study was conducted to compare serum selenium levels in children with and without subclinical hypothyroidism.
Methods: This case-control study was conducted on 103 children aged 3 to 18 years who referred to Amirkola Children's Hospital, Babol, in 2022-2023. The case group consisted of 53 children with normal T4 levels for age and TSH above the normal range of 5.5 MlU/L, and the control group consisted of 50 children with normal growth and thyroid tests and physical examination. T4 and TSH levels were measured by ELISA and selenium level was measured by atomic absorption spectrometry, and the two groups were compared.
Findings: Demographic data of the two groups including age, gender, body mass index, age group, maternal education, paternal education and place of residence did not show a significant difference. 103 children (53 and 50 children with and without subclinical hypothyroidism, respectively) were included in the study. The mean serum selenium was 74.9±26.54 μg/L (76.48 μg/L in the case group and 73.27 μg/L in the control group) and no significant difference was found between the two groups (p=0.883, CI: 0.34-3.48, MD=3.21). Selenium level of children with TSH less than 5.5 was 4.33 units higher than those with TSH greater than 5.5. However, this difference was not significant (p=0.982, CI: 0.43-2.34, OR=1.01).
Conclusion: The results of the study showed that there was no significant difference in serum selenium concentration in children with and without subclinical hypothyroidism. |
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| Keywords: Hypothyroidism, Selenium, Children. |
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Full-Text [PDF 339 kb]
(62 Downloads)
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Type of Study: Case-Control |
Subject:
Children
Received: 2024/06/11 | Accepted: 2024/10/12 | Published: 2025/06/30
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