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:: Volume 18, Number 12 (12-2016) ::
JBUMS 2016, 18(12): 40-48 Back to browse issues page
A Review of the Effective Factors for Lovastatin Production by Aspergillus Terreus Atcc 20542 in Liquid Submerged Fermentation
F Jaberi Ansari, H Jafari Mansoorian *, H Jalili, M Azizi
, h.mansoorian@yahoo.com
Abstract:   (1747 Views)

BACKGROUND AND OBJECTIVE: Deposition of cholesterol in the arteries is the one of the main causes of cardiovascular disease. Lovastatin is a blood cholesterol-lowering drug that inhibits 3-Hydroxy 3-methyl glutaryl-CoA reductase (HMG-CoA reductase) enzyme. The aim of this study was to evaluate the effective factors for lovastatin production by Aspergillus terreus ATCC 20542.

METHODS: This study is a literature review, In order to gather information, articles containing one of the words in their text, including: Cardiovascular disease, Lovastatin, HMG-CoA reductase, Liquid submerged fermentation, Aspergillus terreus were searched between 1960 and 2016 in PUBMED, NATURE, SCIENCE DIRECT and WHO databases.

FINDINGS: A total of 180 papers found that of these, 70 were diagnosed article suitable for this study. According to the results, lactose as the best carbon source, soya been and yeast extract as the nitrogen source, C/N ratio of 41.3, the 107 spores/ml, the pH equal to 6.5, Fe, Zn, Mn as mineral elements and inducer such as linoleic acid at a optimum concentration causes the highest amount of lovastatin.

CONCLUSION: The study shows, the source of carbon and nitrogen, the C/N, the amount and type of inoculation, pH, minerals and inducer are the most important factors affecting the morphology and oxygen uptake by the, Aspergillus terreus and hence also affect the production of lovastatin

Keywords: Biosynthesis, Cardiovascular disease, Lovastatin, HMG-CoA reductase, Aspergillus terreus
Full-Text [PDF 329 kb]   (451 Downloads)    
Type of Study: Review | Subject: Nano
Received: 2016/08/16 | Accepted: 2017/01/15 | Published: 2017/01/29
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DOI: 10.22088/jbums.18.12.40


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Jaberi Ansari F, Jafari Mansoorian H, Jalili H, Azizi M. A Review of the Effective Factors for Lovastatin Production by Aspergillus Terreus Atcc 20542 in Liquid Submerged Fermentation. JBUMS. 2016; 18 (12) :40-48
URL: http://jbums.org/article-1-6283-en.html
Volume 18, Number 12 (12-2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences
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