Protective Effects of Celery (Apium graveloens) Seed Extract on Bleomycin-Induced Pulmonary Fibrosis in Rats
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Iraj Javadi , Mohammadreza Rashidi Nooshabadi * , Mehdi Goudarzi , Rahimeh Roudbari ![](./files/0allsites/images/pubmed20.png) |
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Abstract: (7926 Views) |
BACKGROUND AND OBJECTIVE: Pulmonary fibrosis is one of the most common side effects of
bleomycin which is used as a chemotherapeutic agent. Reactive oxygen species
play a key role in the development of pulmonary fibrosis. Celery seed contains
a variety of flavonoids which are considered as asantioxidants. This study
investigated the effects of celery seed hydroalcoholic extract on
bleomycin-induced pulmonary fibrosis in rats.
METHODS: This empirical study was conducted on 20 Sprague-Dawley rats
weighing from 180 to 150 g. The animals were divided randomly into 5 groups of
4 rats. Groups 1 and 2, respectively, received a single dose of saline or
bleomycin (7.5 units per kg) endotracheally. Group 3-5 received different daily
doses of celery seed extract (100, 200 and 400 mg/kg) intraperitoneally for one
week before and two weeks after the bleomycin. The animals were killed after 21
days and their blood and lungs were collected and tested so as to measure the
plasma malondialdehyde, lung hydroxyproline and histopathology test.
FINDINGS: The results showed that the
index of lung, hydroxyproline and malondialdehyde in the saline normal group
were respectively, 2.02±7.27 milligrams of lung per gram of body weight,
0.24±1.78 mg per gram of lung tissue and 0.17±1.48 micromol per liter of
plasma. On the other hand, in the group receiving bleomycin, the figures were
0.99±10.1, 1.5±5.75 and 0.23±3.27, respectively. Treatment with extract,
especially in groups 4 and 5, significantly reduced these factors compared to
the bleomycin group (p<0.05). Furthermore, the results of histology revealed
that bleomycin could lead to lung damage and the thickening of the alveolar.
CONCLUSION: The results showed that celery seed
hydroalcoholic extract has a protective effect on bleomycin-induced pulmonary
fibrosis. |
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Keywords: KEY WORDS: Pulmonary Fibrosis, Celery Seed Extract, Bleomycin, Rat. |
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Full-Text [PDF 438 kb]
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Type of Study: Review |
Subject:
Nutrition Received: 2014/12/28 | Accepted: 2014/12/28 | Published: 2014/12/28
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