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Investigation of the Effect of Silymarin on the Urotensin II and its Receptor Genes Expression in Liver Tissue of Type 2 Diabetic Rats
N Kheiripour , J Karimi , H Tayebinia , I Khodaddi , MT Goudarzi
, jamshidkarimi2013@gmail.com
Abstract:   (608 Views)
Background: Studies have shown that increases concentration of U-II related with diabetes mellitus disorders. Because herbal medicines have fewer complications than most chemical drugs, in this study we investigated the effects of silymarin on level of glucose, insulin and expression of U-II and U-II receptor (U-II R) genes in rats with type 2 diabetes.
Material and Methods: In this experimental study 36 Male Wistar rats were divided into six groups: 1- control group, 2, 3-control received silymarin 60 and 120 mg/kg daily respectively, 4- type 2 diabetic by intraperitoneal injection of 60 mg/kg streptozotocin and 120 mg/kg nicotinamide, 5, 6- diabetic received silymarin 60 and 120 mg/kg daily respectively. This treatment continued for 60 days. Serum and liver tissue samples were collected from all animals. Glucose, insulin, HOMA-IR, liver enzymes in the serum by spectrophotometric and ELISA methods, and mRNA expressions in liver by quantitative polymerase chain reaction were evaluated.
Results: In diabetic groups treated with silymarin (60 and 120 mg/kg), insulin was significantly increased in comparison with the diabetic group (p<0.05). Also, glucose level, HOMA-IR, liver enzymes, U-II and U-II R gene expression declined significantly (p<0.05).
Conclusion: The results of the study showed that administration of silymarin improves liver function in diabetic rats.
 
Keywords: Diabetes Mellitus, Silymarin, Urotensin II, Urotensin II Receptor, Liver
     
Type of Study: Experimental | Subject: Biochemical
Received: 2018/09/6 | Accepted: 2019/01/8 | Published: 2019/01/23
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Kheiripour N, Karimi J, Tayebinia H, Khodaddi I, Goudarzi M. Investigation of the Effect of Silymarin on the Urotensin II and its Receptor Genes Expression in Liver Tissue of Type 2 Diabetic Rats. JBUMS. 2019; 21
URL: http://jbums.org/article-1-8143-en.html


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مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

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