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:: Volume 20, Issue 10 (10-2018) ::
JBUMS 2018, 20(10): 0-0 Back to browse issues page
Effects of maternal separation on morphine dependency and LTP induction in hippocampal CA1 neurons of rats
F Aghighi , M Mohammadifar , M Salami , Gh Hamidi , SA Talaei
Physiology Research Center, Kashan University of Medical Sciences, Kashan, I. R. Iran , talaei@kaums.ac.ir
Abstract:   (94 Views)
Background and Objective: Maternal separation as a stressor causes disruption of cognitive and neuro-chemical activities of the brain. The aim of this study was to investigate the effects of maternal separation on morphine dependence and synaptic plasticity of CA1 area neurons of rats.
Methods: This experimental study was conducted on 40 male 45 days old rats. Animals were divided into control group (CO), morphine dependent (MD) and 3 groups of rats which maternally separated during 1 (MS1), 2 (MS2) and 3 weeks (MS3) after birth. Except CO rats, the other groups were subcutaneously injected 10 mg/kg morphine every 12 hours for 10 days. At the 11th day signs of withdrawal syndrome were evaluated and at the next day field excitatory post synaptic potentials (fEPSPs) were recorded in the CA1 area for 30 minutes. Then, using the tetanic stimulation, LTP was induced.
Findings: Maternal separation increased morphine dependency of rats. Although morphine dependence did not affect basic responses of CA1 area neurons and LTP induction, but maternal separation decreased amplitude of basic responses (P<0.001) and inhibited LTP induction (P<0.001), time dependently.
Conclusion: Maternal separation increases dependency of rats to morphine and also disrupts synaptic plasticity of hippocampal neurons of morphine dependent rats, conclusively.
Keywords: Morphine, Maternal separation, Long-term potentiation, Hippocampus, Rat
Type of Study: Interventional | Subject: Phisiology
Received: 2018/02/11 | Accepted: 2018/09/3 | Published: 2018/10/7
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Aghighi F, Mohammadifar M, Salami M, Hamidi G, Talaei S. Effects of maternal separation on morphine dependency and LTP induction in hippocampal CA1 neurons of rats. JBUMS. 2018; 20 (10)
URL: http://jbums.org/article-1-7588-en.html

Volume 20, Issue 10 (10-2018) Back to browse issues page
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