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:: Volume 20, Issue 12 (11-2018) ::
JBUMS 2018, 20(12): 0-0 Back to browse issues page
Comparison between the effect of Yoghurt starter bacteria and Lactobacillous bulgaricus on Peripheral blood mononuclear cells activity of ulcerative colitis patients
A Sheikhi , Z Ahmadi , M Askari
, zeynab.ahmadi20@gmail.com
Abstract:   (476 Views)
BACKGROUND AND OBJECTIVE: Ulcerative colitis is an inflammatory bowel disease and involving colon and rectum. The purpose of this study is comparison of the effect of yoghurt starter bacteria and Lactobacillous bulgaricus on the peripheral blood mononuclear cells (PBMC) of ulcerative colitis patients.
METHODS: This experimental-laboratory study was performed on 10 ulcerative colitis patients in Dezful, Andimeshk and Shoosh in two experimental groups and a control group. Experimental groups included co-culture of PBMC and intended bacteria in dilutions of 0.1 and 0.01 and at 48 and 72 hours, and control group including PBMC of the patient at 48 and 72 hours. Variables (IL10 and IL1β) by ELISA were measured at a significant level of P<0.05 and in the form of Mean±SD.
FINDINGS: There was a significant increase in the secretion of IL1β at dilution of 0.1 and 48 hours by PBMC stimulated with bulgaricus 940.4±249.61 in comparison with the starter 669.12±181.11 (P=0.004) and in 72 hours by bulgaricus 796.3±213.34 in comparison with the starter 464.25±128.41 (P=0.000), In dilution of 0.01 and 48 hours by bulgaricus 747.5±198.54 in comparison with starter 529.25±163.82 (P=0.005) and in 72 hours by bulgaricus 617.4±192.5 in comparison with starter 408.62±134.78 (P=0.004). Also, there was a significant increase in the secretion of cytokines in both dilution and both times between of the experimental groups and control.
CONCLUSION: Lactobacillus bulgaricus causes inflammation in comparison with the starter by IL1β secretion. Starter bacteria has a better role in reducing inflammation.
KEY WORDS: Ulcerative colitis, Starter, Lactobacillous bulgaricus
 
Keywords: Ulcerative colitis, starter, Lactobacillous bulgaricus
     
Type of Study: Experimental | Subject: Mi
Received: 2018/01/2 | Accepted: 2018/10/29 | Published: 2018/11/21
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Sheikhi A, Ahmadi Z, Askari M. Comparison between the effect of Yoghurt starter bacteria and Lactobacillous bulgaricus on Peripheral blood mononuclear cells activity of ulcerative colitis patients. JBUMS. 2018; 20 (12)
URL: http://jbums.org/article-1-7454-en.html


Volume 20, Issue 12 (11-2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

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