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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 20, Issue 6 (6-2018) ::
J Babol Univ Med Sci. 2018; Volume 20 Back to browse issues page
Lack of Genetic Association between Interleukin-18 Gene Polymorphism (rs1946518) and Chronic Hepatitis B Infection
M Salehi , SR Mohebbi * , M Karkhane , Sh Kazemian , P Azimzadeh , M Saeedi Niasar , A Sharifian , MR Zali
2- Gastroenterology and liver diseases research center, Research institute for gastroenterology and liver diseases, Shahid Beheshti university of medical Sciences, Tehran, Iran , srmohebbi@gmail.com
Abstract:   (3498 Views)
BACKGROUND AND OBJECTIVE:  Interleukin 18 is a member of the cytokines that play an important role in the Th1-mediated immune response by inducing interferon-gamma activity in collaboration with Interleukin-12 (IL-18). Interleukin 12 and Interleukin 18 can play an important role in purifying viruses. Considering the importance of IL-18, this study was conducted to investigate the relationship between Interleukin-18 Gene polymorphism (-607 C/A: rs1946518) and the susceptibility to chronic hepatitis B infection.
METHODS: In this case-control study, the genomic DNA of 115 patients with chronic hepatitis B (with positive results of HBsAg and Anti-HBcAb serology testing) and 115 non-HBV-infected controls (negative results of HBsAg and Anti-HbcAb serology testing and no history of liver disease) was extracted by salting-out method and the genotype of single-nucleotide polymorphism (-607 C / A: rs1946518) was sequenced using PCR-RFLP method. 
FINDING: The genotype frequency of TT, GT, and GG in patients was 40%, 49.6%, and 10.4% in patients, and 41.7%, 42.6%, and 15.7% in the control group, respectively. No significant difference was found between the patients group and the control group.
CONCLUSION: Based on the results of this study, there was no clear relationship between IL-18 polymorphism and the potential for chronic hepatitis B infection. Therefore, this polymorphism cannot be a potential factor for chronic hepatitis B.
Keywords: Interleukin 18, Chronic Hepatitis, Hepatitis B Virus, Single-Nucleotide Polymorphism
Full-Text [PDF 207 kb]   (1080 Downloads)    
Type of Study: Case-Control | Subject: Virology
Received: 2017/12/2 | Accepted: 2018/07/8 | Published: 2018/07/23
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Salehi M, Mohebbi S, Karkhane M, Kazemian S, Azimzadeh P, Saeedi Niasar M, et al . Lack of Genetic Association between Interleukin-18 Gene Polymorphism (rs1946518) and Chronic Hepatitis B Infection. J Babol Univ Med Sci 2018; 20 (6) :46-52
URL: http://jbums.org/article-1-7360-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 6 (6-2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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