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:: Volume 20, Issue 3 (3-2018) ::
JBUMS 2018, 20(3): 0-0 Back to browse issues page
Histological Analysis of Type of Mast Cells in Random Skin Flaps by Bone Marrow Mesenchymal Stem Cells through Biological Growth Factor.
F Chehelcheraghi *, Kh Anbari
, fr.chehelcheraghi@gmail.com
Abstract:   (145 Views)
Abstract
 
Introduction:
 The skin flap is one of the most commonly used methods in plastic surgery. Flap necrosis is a complication of skin flaps. The aim of this study was to evaluate the effect of bone marrow mesenchymal cells (BM-MSCs) and chick embryo extract (CEE) on mast cells in  Random Skin flap(RSF) in rat.
Materials and Methods:
40 male albino Wistar rats weighing 250-300g were divided into four groups (Control, CEE / BM-MSCs, CEE and BM-MSCs). The RSF(80mm × 30) was placed behind the animals. The surgery  day  was day zero and  treatment intervention on this day. Mesenchymal stem cells were extracted from rat bone marrow. CEE was prepared from a 9 days fetal chicken breed of Marandi. On the seventh day after the surgery, samples were taken to evaluate all types of mast cells in the transitional line.
Results:
 Based on the ANOVA, the results were as follows: The difference between the mean number of type 1 mast cells (P = 0.099), type 2 (P = 0.384) in the study groups was not statistically significant, but in type 3, was significant (P = 0.001). There was a statistically significant difference between the mean total number of mast cells in the BM-MSCs receiving group with other experimental groups (P=0.001).
Discussion and results:
Increase of type 2 of mast cells,improveing microvessels  and decreasing  type 3, cause to reduce  scar and  fibrosis .
Keywords: Biological Factors, Mast Cells, Surgical Flap
     
Type of Study: Experimental | Subject: Baft
Received: 2017/09/26 | Accepted: 2018/01/24 | Published: 2018/02/13
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Chehelcheraghi F, Anbari K. Histological Analysis of Type of Mast Cells in Random Skin Flaps by Bone Marrow Mesenchymal Stem Cells through Biological Growth Factor.. JBUMS. 2018; 20 (3)
URL: http://jbums.org/article-1-7154-en.html


Volume 20, Issue 3 (3-2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

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