BACKGROUND AND OBJECTIVE: The family history of breast and prostatism cancer is a risk factor for prostate cancer. Considering the common pathogens for prostate and breast cancers, the aim of this study was to determine the relationship between the patient's prostate cancer and their first and second-class relatives with the history of breast cancer.
METHODS: This case-control study was conducted on 300 patients who underwent biopsy in Shahid Beheshti hospital due to prostate enlargement. Patients were divided into two groups based on biopsy: a) prostate cancer in case group and benign prostate enlargement in control group. Additional information of the first and second-class relatives of patients was collected in the checklist and evaluated. The patients (150 control, 150 experimental) were selected using simple sampling method. The experimental and control groups who underwent biopsy suffered from prostate cancer and benign prostate enlargement, respectively. Additional information was collected in the checklist and evaluated for patients in the first and second grade families.
FINDINGS: The mean age of patients was 72.17±9.788 and 70.01±9.921 in case and control group, respectively. The frequency of breast cancer in the family of patients with prostate cancer and healthy persons was 16 (59.3%) and 11 (40.3%), respectively and the frequency of prostate cancer was 26(17.3%) and 2(1.3%), respectively (p <0.001). The frequency of breast cancer was greater in first than second grade familie in both groups. In both groups, the history of breast cancer was higher in patients older than 40 years.
CONCLUSION: The results of the study indicated that the frequency of prostate cancer is probably higher if the first and second-class relatives affect with prostate cancer than breast cancer.