Frequency of Vitamin D Deficiency in Common Musculo Skeletal Conditions
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Behzad Heidari * , Parham Heidari , Elham Samari , Moazameh Ramzannia Jalali |
, bheidari6@gmail.com |
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Abstract: (9046 Views) |
BACKGROUND
AND OBJECTIVE: Vitamin D deficiency is an important known responsible factor for
development,progression and exacerbation of many musculoskeletal disease.The
aim of the present study was to determine the status of serum vitamin D in a
number of common musculoskeletal conditions presented an outpatient
rheumatology clinic. METHODS: Pateints
with musculoskeletal presentations having
symptoms for at least three months entered the study.Serum vitamin D was
determined by assessment of serum 25-hydroxyvitamin D (25-OHD) using ELISA
method, and levels less than 20 ng/ml was considered as deficiency. The primary
objective of this study was to compare serum 25-OHD level and frequency of
25-OHD deficiency between patients with musculoskeletal symptoms
and controls. The secondary objective was to determine the relationship
between serum 25-OHD deficiency and musculoskeletal conditions with respect to
age and sex. FINDINGS: 1099 patients (910 females) including 291 (26.47%) patients with
knee OA,192 (17.47%) with rheumatoid arthritis (RA), 76 (6.9%) with
non-rheumatoid arthritis inflammatory arthritis (NRAIA),
237 (21.56%)
patients
with nonspecific skeletal pain, 163(14.83%) patients with low back pain (LBP), 114(10.37%)
patients with arthralgia,and 26(2.36%) patients with inflammatory back pain (IBP) entered the
study to compare with 374 (243 females) controls. Serum 25-OHD levels
and frequency of 25-OHD deficiency in knee OA, RA,
NRAIA,
IBP did not differ significantly with the control group,
but
in patients with nonspecific musculoskeletal pain and low back pain serum
25-OHD levels were significantly lower than controls.
Serum
25-OHD deficiency increased the risk of nonspecific skeletal pain, LBP by 3.9 and 3.32 times respectively
(p=0.001 for both). The association was
greater in women as compared with men.In patients aged less than 55 years,
25-OHD deficiency increased the risk of knee OA 1.71 times
(p=0.014) and the risk of arthralgia 1.84
times (p=0.018).
CONCLUSION: Vitamin D
deficiency is significantly related with a number of common musculoskeletal
conditions like nonspecific skeletal pain,
LBP, arthralgia, according to
age and sex. This issue requires further prospective, in particular
placebo-controlled studies, to determine
efficacy of supplemental vitamin D on skeletal symptoms by comparison of
symptoms before and after supplementation. |
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Keywords: KEY WORDS: Vitamin D deficiency, Knee osteoarthritis, Inflammatory arthritis, Nonspecific skeletal pain. |
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Full-Text [PDF 212 kb]
(2860 Downloads)
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Type of Study: Experimental |
Subject:
Physiology Received: 2014/11/19 | Accepted: 2014/11/19 | Published: 2014/11/19
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