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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 16, Issue 12 (12-2014) ::
J Babol Univ Med Sci. 2014; Volume 16 Back to browse issues page
Frequency of Vitamin D Deficiency in Common Musculo Skeletal Conditions
Behzad Heidari * , Parham Heidari , Elham Samari , Moazameh Ramzannia Jalali
, bheidari6@gmail.com
Abstract:   (9046 Views)

BACKGROUND AND OBJECTIVE: Vitamin D deficiency is an important known responsible factor for development,progression and exacerbation of many musculoskeletal disease.The aim of the present study was to determine the status of serum vitamin D in a number of common musculoskeletal conditions presented an outpatient rheumatology clinic.

METHODS: Pateints with musculoskeletal presentations having  symptoms for at least three months entered the study.Serum vitamin D was determined by assessment of serum 25-hydroxyvitamin D (25-OHD) using ELISA method, and levels less than 20 ng/ml was considered as deficiency. The primary objective of this study was to compare serum 25-OHD level and frequency of 25-OHD deficiency between  patients with musculoskeletal  symptoms and controls.  The secondary objective was to determine the relationship between serum 25-OHD deficiency and musculoskeletal conditions with respect to age and sex.

FINDINGS: 1099 patients (910 females) including 291 (26.47%) patients with knee OA,192 (17.47%) with rheumatoid arthritis (RA), 76 (6.9%) with non-rheumatoid arthritis inflammatory arthritis (NRAIA), 237 (21.56%) patients with nonspecific skeletal pain, 163(14.83%) patients with low back pain (LBP), 114(10.37%) patients with arthralgia,and 26(2.36%) patients with inflammatory back pain (IBP) entered the study to compare with 374 (243 females) controls. Serum 25-OHD levels and frequency of 25-OHD deficiency in knee OA, RA, NRAIA, IBP did not differ significantly with the control group, but in patients with nonspecific musculoskeletal pain and low back pain serum 25-OHD levels were significantly lower than controls. Serum 25-OHD deficiency increased the risk of nonspecific skeletal pain, LBP by 3.9 and 3.32 times respectively (p=0.001 for both). The association was greater in women as compared with men.In patients aged less than 55 years, 25-OHD deficiency increased the risk of knee OA 1.71 times (p=0.014) and the risk of arthralgia 1.84 times (p=0.018).

CONCLUSION: Vitamin D deficiency is significantly related with a number of common musculoskeletal conditions like nonspecific skeletal pain, LBP, arthralgia, according to age and sex. This issue requires further prospective, in particular placebo-controlled studies, to determine efficacy of supplemental vitamin D on skeletal symptoms by comparison of symptoms before and after supplementation.

Keywords: KEY WORDS: Vitamin D deficiency, Knee osteoarthritis, Inflammatory arthritis, Nonspecific skeletal pain.
Full-Text [PDF 212 kb]   (2860 Downloads)    
Type of Study: Experimental | Subject: Physiology
Received: 2014/11/19 | Accepted: 2014/11/19 | Published: 2014/11/19
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Heidari B, Heidari P, Samari E, Ramzannia Jalali M. Frequency of Vitamin D Deficiency in Common Musculo Skeletal Conditions. J Babol Univ Med Sci 2014; 16 (12) :7-15
URL: http://jbums.org/article-1-5147-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 12 (12-2014) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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