Effect of Apium Graveolens Leaf Extract on Serum Level of Thyroid Hormones in Male Rat
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Wassam Kooti , Akram Ahangarpoor , Maryam Ghasemiboroon , Sahar Sadeghnezhadi , Zahra Abbasi , Ziba Shanaki , Zahra Hasanzadeh-Noohi , Majid Asadi-Samani * |
, biology_2011@yahoo.com |
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Abstract: (12748 Views) |
BACKGROUND AND
OBJECTIVE: Celery (Apium graveolens) is a medicinal plant with antioxidant
benefits and rich of flavonoid. Since flavonoids have great impact on
physiological functions of body and especially thyroid function, the aim of
this study was to investigate the effect of hydro- alcoholic extract of celery
leaf on serum level of thyroid hormones.
METHODS: In this
experimental study, 40 male rats were divided into 5 groups of eight rats each.
They were control, sham (received normal saline) and the experimental groups
received 1 ml of hydro- alcoholic extract of celery
with doses of 50,100 and 200 mg/kg during 21 days by using gavage method. One
day after the last gavage, the blood samples were collected by bloodletting
from the heart. After preparing serum, the level of T3، T4 and TSH hormones were measured using ELISA
method.
FINDINGS: The serum levels of T3 (0.95±0.04 and 0.95±0.06, respectively)
and T4 (5.42±0.85 and 5.87±0.89, respectively)
hormones decreased (p<0.05) in the rats
received celery leaf extract with doses of 50 and 100 mg/kg serum and TSH (1.93±0.06 and
1.96±0.08, respectively) had
significant increase (p<0.001) in comparison with control group (1.63±0.33,
8.96±0.43, and 1.11±0.10, respectively). In
rats received celery leaf extract with dose of 200 mg/kg, the serum level of T4
(5.90±0.45)
hormone increased significantly in comparison
with the sham group (p<0.01), but that of TSH and T3 hormones had
no significant changes compared to control group (p>0.05).
CONCLUSION: The results showed that prescribing these doses of celery extracts
caused the decrease of thyroid hormone level so it could be considered as a balance hyperthyroidism. |
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Keywords: KEY WORDS: Apium graveolens, Triiodothyronine, Thyroxin, Thyroid-stimulating hormone, Rat. |
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Type of Study: Case-Control |
Subject:
Dentistry (Peru) Received: 2014/10/21 | Accepted: 2014/10/21 | Published: 2014/10/21
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