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:: Volume 17, Issue 4 (4-2015) ::
J Babol Univ Med Sci. 2015; Volume 17 Back to browse issues page
The Effect of Omega-3 on the Level of Serum Lipid Profile, Adipocytokines, and Indicator of Vascular Inflammation in Patients Diagnosed with Myocardial Infarction
Fatemeh Haidari , Mahshid Tavakoli , Habib Heybar , Bijan Helli , Majid Mohamadshahi *
Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , shahi334@gmail.com
Abstract:   (8481 Views)

BACKGROUND AND OBJECTIVE: Changes in inflammatory mediators have an important role in myocardial infraction. Since the anti-inflammatory effects of Omega-3 fatty acids on cardiovascular diseases was reported, this study was done to evaluate the Omega-3 effect on serum lipid profile, leptin, adiponectin, and E-selectin in patients with myocardial infraction.

METHODS: In this double blinded clinical trial study, 42 patients with myocardial infraction were randomly divided into two mediator and control group. For 10 weeks, the mediator group received 3 capsules of 1 gram Omega-3 daily, and the control group received 3 capsules of placebo (paraffin) daily. Concentration of serum lipid profile, leptin, adiponectin, and E-selectin was measured and compared at the beginning and at the end of the test. IRCT=2021070410181N1

FINDINGS: At the end of the study, after comparing the Omega-3 receiving group with placebo group, there was a significant decrease of serum level of triglyceride (120.04±53.24 versus 150.76±48.84, p=0.021), leptin (6.92±2.71 versus 9.05±2.66, p=0.007), and E-selectin (20.98±10.04 versus 6.55±4.12), and there was a significant increase in the serum level of adiponectin (7.24±3.50 versus 6.55±4.12, p=0.026) in patients with myocardial infraction. In both groups, improvement in the size of blood lipids (TC, LDL-C, HDL-C) was obvious when compared to the primary sizes (p<0.05) but the difference between the two complementary and placebo group was not statistically significant.

CONCLUSION: The results show that receiving Omega-3 on a daily basis can modulate inflammatory factors in patients with myocardial infraction.

Keywords: Omega-3, Myocardial Infraction, Adiponectin, Leptin, E-selectin, Lipid Profile
Full-Text [PDF 402 kb]   (2773 Downloads)    
Type of Study: Research | Subject: Nutrition
Received: 2014/06/22 | Accepted: 2015/03/10 | Published: 2015/03/17
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Haidari F, Tavakoli M, Heybar H, Helli B, Mohamadshahi M. The Effect of Omega-3 on the Level of Serum Lipid Profile, Adipocytokines, and Indicator of Vascular Inflammation in Patients Diagnosed with Myocardial Infarction. J Babol Univ Med Sci 2015; 17 (4) :7-17
URL: http://jbums.org/article-1-4837-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 4 (4-2015) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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