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Effects of Sesame Oil on Improving Spatial Memory in Alzheimers Disease
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F Fathi   , H Hatami * , AR Ali Hemmati , S.M Banan Khojasteh |
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Abstract: (12019 Views) |
BACKGROUND AND OBJECTIVE: Alzheimers disease is the most common neurodegenerative diseases. According to the positive effects of unsaturated fatty acids of sesame oil on neurons membrane and causing defense against free radicals, the aim of this study was to investigate the reinforcing effects of sesame oil on spatial memory in Alzheimers rat.
METHODS: In this experimental study, 35 male rats weighing approximately 200±50 gram were divided in five equal groups: control, sham (salin recipient), Alzheimers model (ICV injection of streptozotocin) and 2 groups of Alzheimers model + sesame oil pretreatment (8 and 5 ml/kg by IP for 28days). Alzheimers model was induced by ICV injection of streptozotocin (1.5 mg/kg). The Morris Water maze was used for studying the spatial learning memory.
FINDINGS: Intraventricular injection of streptozotocin damaged the spatial memory. Pretreatment of sesame oil (5 and 8 ml/kg 28 days by ip injection) significantly (p<0.05) improved the reduced spatial memory in Alzheimers rat.
CONCLUSION: Long-term pretreatment of rats with sesame oil prevents from reduced spatial memory in Alzheimer’s rat.
Please cite this article as follows:
Fathi F, Hatami H, Ali Hemmati AR, Banan Khojasteh SM. Effects of sesame oil on improving spatial memory in Alzheimers disease. J Babol Univ Med Sci 2014 16(2): 34-41.
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| Keywords: Alzheimer, Sesame Oil, Spatial memory. |
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Full-Text [PDF 528 kb]
(3587 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/06/7 | Published: 2014/06/7
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