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Bone Marrow Transplantation in Seven ?-Thalassemia Major Patients in Amirkola Children Hospital of Babol, Iran (2010-2011) Case Series
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H Mahmoodi Nesheli *   , A Hadipour , S.KH Banihashemi , M Behkar , M Hoseinzadeh Saljoghi , Z Ali Nattaj , S.A Banihashemi , M Mikaniki |
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Abstract: (8182 Views) |
ABSTRACT
BACKGROUND AND OBJECTIVE: Without bone marrow transplantation (BMT), ?- thalassemia major (?-TM) patient needs regular blood transfusion. Iron deposition after blood transfusion causes many unwanted effects. BMT obviates the need for blood transfusion in ?-TM. In this study, bone marrow transplantation in seven ?-thalassemia major patients in Amirkola children hospital was reported.
CASES: Among ?-thalassemia major patients for doing BMT seven patients [4 girls (57%) and 3 boys (42%)] had human leukocyte antigen (HLA) matched donors. Mean age of patients was 10.86±5.58 years. Three donors were sisters, two donors were brothers, one donor was father and one donor was aunt. Hematopoietic stem cells (HSCs) collected from bone marrow (4=57%) and peripheral blood stem cells (PBSc) (3=42%). There was no engraftment failure or graft rejection. One patient suffered from acute graft versus-host disease (GVHD) (stage IV). Mean duration of hospitalization was 37.71±10.32 days. Mean duration of follow up was 353.14±152.133 days. At present all patients are alive, disease free and independent blood transfusion. Chimerism in all of them was more than %90 in the last assessment.
CONCLUSION: The results of this study showed that all studied patients became independent to blood transfusion after BMT. There was no engraftment failure or graft rejection.
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| Keywords: Bone marrow transplantation, ?-thalassemia major, Graft versus host disease, Graft failure. |
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Full-Text [PDF 207 kb]
(1539 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/06/11 | Published: 2014/06/11
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