[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Ethics::
peer-review::
Indexing::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal DOI

AWT IMAGE

..
Copyright Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
This Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0
..
:: Volume 13, Issue 4 (7-2011) ::
J Babol Univ Med Sci. 2011; Volume 13 Back to browse issues page
Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat
M Zaheri * , S Ebrahimi Vosta Kalai , J Cheraghi
Abstract:   (6768 Views)
BACKGROUND AND OBJECTIVE: Most of these contaminants, by increased production of free radicals of oxygen, cause nephrotoxicity in human and experimental animals. Anti-oxidant structures existing in the medicinal plants are suitable candidates for protection against poisoning by these substances. In the present research, for the first time, the effect of the alcoholic juice of the aerial sections of scrophularia striata (Teshnehdaru) on nephrotoxicity caused by cadmium and mercury is investigated.
METHODS: Forty two male Wistar rats (200-250 g) were randomly divided into 6 groups (n=7) to receive a daily corresponding dose of cadmium chloride (3mg/kg, i.p., group Cd), mercuric chloride (1.5mg/kg, i.p., group Hg), extract of Scrophularia striata (400 mg/kg, i.p., group Ss), combination extract and cadmium chloride (CS), combination extract and mercury chloride (HS) and normal saline as control (CT). At the end of the 8 day blood samples were collected and nephrotoxicity was evaluated by measuring serum urea, serum creatinine, blood urea nitrogen (BUN) and uric acid concentration.
FINDINGS: Administration of hydroalcoholic extract of Scrophularia striata induced a significant decrease urea and uric acid compared with control group. Cd- induced increases in urea, creatinine, BUN and uric acid were significantly reduced by treatment with extract. In compared with control group in Hg group uric acid and creatinine increased but urea and BUN decreased. Treatment with extract improved nephrotoxicity.
CONCLUSION: The results showed that scrophularia striata may have a protective effect against heavy metal induced nephrotoxicity.
Keywords: Scrophularia striata, Nephrotoxicity, Mercury, Cadmium
Full-Text [PDF 204 kb]   (2005 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/06/7 | Published: 2014/06/7


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zaheri M, Ebrahimi Vosta Kalai S, Cheraghi J. Protective Effect of Aerial Parts Extract of Scrophularia Striata on Cadmium and Mercury-Induced Nephrotoxicity in Rat. J Babol Univ Med Sci 2011; 13 (4) :48-53
URL: http://jbums.org/article-1-3842-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 4 (7-2011) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Persian site map - English site map - Created in 0.06 seconds with 43 queries by YEKTAWEB 4645