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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 13, Issue 4 (7-2011) ::
J Babol Univ Med Sci. 2011; Volume 13 Back to browse issues page
Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients
P Azimzadeh * , SR Mohebbi , S Romani , SH Kazemian , H Irtalebi , M Vahedi , F Derakhshan , MR Zali
Abstract:   (6605 Views)
BACKGROUND AND OBJECTIVE: Transforming growth factor beta (TGF-β) has an inhibitory role in homeostasis of T-cell response and regulatory T cells and regulation of immune response against viral infections. Codon 10 of protein is located in the signal peptide and involved in secretion of cytokine. The aim of this study was to investigate the association of leu-pro polymorphism of codon 10 and hepatitis C susceptibility in patients.
METHODS: This case-control study was performed on 112 chronic hepatitis C patients and 122 healthy control subjects. TGF-β1 gene was amplified with PCR method and genotypes were determined using Restriction Fragment Length Polymorphism (RFLP) with MspA1I restriction enzyme.
FINDINGS: The frequency of CT genotype in both groups was higher than CC and TT. Genotyping results for CC, CT and TT states in patients was 50%, 19.6% and 30.4% and in healthy controls was 59%, 13.9% and 27.1% respectively. We found no significant difference between patients and healthy controls according to codon 10 polymorphism.
CONCLUSION: According to the results of this study, no relationship was found between this protein’s genetic variations and chronic hepatitis C infection susceptibility.
Keywords: Hepatitis C, Cytokine, Polymorphism
Full-Text [PDF 334 kb]   (1693 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/06/7 | Published: 2014/06/7


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Azimzadeh P, Mohebbi S, Romani S, Kazemian S, irtalebi H, Vahedi M, et al . Role of TGF-β1 Codon 10 Polymorphism in Chronic Hepatitis C Patients. J Babol Univ Med Sci 2011; 13 (4) :26-33
URL: http://jbums.org/article-1-3839-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 4 (7-2011) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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