[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Ethics::
peer-review::
Indexing::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal DOI

AWT IMAGE

..
Copyright Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
This Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0
..
:: Volume 13, Issue 1 (2-2011) ::
J Babol Univ Med Sci. 2011; Volume 13 Back to browse issues page
A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia
M Kashifard * , E Alijanpour , M Hoseinian
Abstract:   (7547 Views)
BACKGROUND AND OBJECTIVE: Halothane is the most common inhalation anesthetic drug in the world and there is an increasing interest for using intravenous anesthetics like propofol. The purpose of this study was to compare the effect of halothane and propofol on hepatic enzymes after general anesthesia.
METHODS: This randomized clinical trial study was performed on 58 patients (14-69 years old) classified in class I of American Society of Anesthetics. These patients who had no preliminary symptomatic hepatic, cardiac or renal disease admitted for elective surgery (ENT, eye, orthopedics, general surgery, and urology). These patients were divided randomly into two groups: 30 patients in the propofol group and 28 patients in the halothane group. In both groups, pre-medication and induction of anesthesia were the same. For the maintenance of anesthesia in the study group there was continuous infusion of propofol and for the control group, 0.5-1% halothane inhalation. From all the patients, three blood samples were taken separately prior to the anesthesia, twenty four hours and seven days after the anesthesia. These samples were tested and compared for aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphates (ALP) and Billirubin (total and direct)
FINDINGS: Mean anesthesia duration in propofol group was 91±14.7 minute and in halothan group was 93.2±17 minute that there was not statistically significant difference in duration of anesthesia between the two groups. Seven days after anesthesia ALP, the total and direct billirubine levels did not show significant differences between the two groups. However, AST (p=0.008) and ALT (p=0.003) increased in halothane group in compared with propofol group.
CONCLUSION: The results show that propofol has less effect on liver enzymes as compared to halothane. This can be considered in anesthetic drug usage.
Keywords: Halothane, Propofol, Liver enzymes, General anesthesia
Full-Text [PDF 179 kb]   (1358 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/06/7 | Published: 2014/06/7


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kashifard M, Alijanpour E, Hoseinian M. A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia. J Babol Univ Med Sci 2011; 13 (1) :7-13
URL: http://jbums.org/article-1-3714-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 1 (2-2011) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Persian site map - English site map - Created in 0.07 seconds with 43 queries by YEKTAWEB 4645