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:: Volume 10, Issue 6 (1-2009) ::
J Babol Univ Med Sci. 2009; Volume 10 Back to browse issues page
EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE
M.R. Nikravesh, M. Jalali, A.R. Fazel
Abstract:   (18391 Views)
BACKGROUND AND OBJECTIVE: Formaldehyde is one of agents with absorbable potential which can use in industry and also in many productions such as technical, pharmaceutical and sanitary compounds. Previous study shown that formaldehyde can affect on testicular tissue and reduce spermatogenesis phenomena. This study was carried out to determine the effects of formaldehyde on leydig cells and testicular vasculogenesis.
METHODS: Twenty mature male Balb/c mice were randomly divided into experimental and control groups (n=10). Experimental group were administered 0.25 mg/kg body weight dissolved formaldehyde intraperitoneally for 10 days. The control groups were received the same volume of normal saline during the same period of times. At the end of exposure time, animals were scarified and their testes were removed for processing, serially sectioned and immunohistochemistry by using PCNA method were carried out.
FINDINGS: The finding revealed that the numerical density of leydig cells decreased significantly in experimental group in contrast controls (42 versus 66 per/m3 respectively). In addition, a number of shrinkage and picnotic leydig cells indicated occurrence of chromatolysis phenomena in experimental group.
CONCLUSION: These data reveal that administration of formaldehyde may result in significant structural changes in male reproductive system such as interstitial tissue of seminiferous tubules and cell death among leydig cells population.
Keywords: Formaldehyde, Immunohistochemistry, Testis interstitial tissue, Mouse
Full-Text [PDF 442 kb]   (2353 Downloads)    
Type of Study: Research | Subject: Biochemical
Published: 2009/01/15


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M.R. Nikravesh, M. Jalali, A.R. Fazel. EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE. J Babol Univ Med Sci 2009; 10 (6) :23-30
URL: http://jbums.org/article-1-3109-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 6 (1-2009) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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