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Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats
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M Pour Ghasem *   , M Jalali , M Nikravesh , M Behnam Rasoli , N Aminian |
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Abstract: (13447 Views) |
| Objective: Diabetes mellitus is a metabolic disease due to failure in insulin secretion function. Kidney is a target organ in diabetes. Diabetic nephropathy is a major cause of end stage renal disease and resulting in increased morbidity and mortality of affected individuals. Since diabetes is a progressive disease, early diagnosis serves better treatment. Methods: We induced diabetes in rat by alloxan administration after 8 weeks. We detected lipofuscin products with H&E, PAS and schmorl’s staining methods. Findings: Diabetic rats showed increasing lipofuscin in renal proximal tubular cells. Conclusion: Increased lipofuscin pigments is a good indicator for diagnosis of diabetes in rats. |
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| Keywords: Diabetes mellitus, Lipofuscin, Alloxan, Kidney |
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Full-Text [PDF 1245 kb]
(2319 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/05/25 | Published: 2014/05/25
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