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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
This Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0
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:: Volume 2, Issue 3 (7-2000) ::
J Babol Univ Med Sci. 2000; Volume 2 Back to browse issues page
Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo
SN Ostad * , M Abdollahi , M Akbari , H Marzban , N Babolmorad
Abstract:   (10027 Views)
Objective: Dexamethasone and Hydrocortisone are two glucocorticoids widely used to alleviate moderate to acute inflammation. But due to their different pharmacokinetics, potential of these drugs in initiation of abnormalities is not equivalent with their pharmacologic activities. Their different pharmacokinetics of absorption, distribution and metabolism result in production of different teratogenic effects on the embryo that may not be parallel to pharmacological potencies. Methods: After an incubation of 20 days, we removed the chick embryos from the eggs and studied the effects of drugs in development of abnormalities like embryonic toxicity. Findings: Results of this investigation showed that dexamethasone and hydrocortisone induce remarkable malformation in the doses of 4*10-4 mg and 2*10-1 mg respectively. Conclusion: This study showed that in the same dose dexamethasone is 500 times more potent than hydrocortisone in term of teratogenicity.
Keywords: Dexamethasone, Hydrocortisone, Teratogenic, Chick embryo, Toxicity
Full-Text [PDF 834 kb]   (1975 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/05/25 | Published: 2014/05/25


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Ostad S, Abdollahi M, Akbari M, Marzban H, Babolmorad N. Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo. J Babol Univ Med Sci 2000; 2 (3) :12-16
URL: http://jbums.org/article-1-2898-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2, Issue 3 (7-2000) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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