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Colonic perforation in a kidney recipient with Cytomegalovirus (CMV) colitis
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F Oliaei *   , N Eshkevari , E Shafigh |
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Abstract: (8359 Views) |
| Background and Objective: Gastrointestinal (GI) involvement is a cause of morbidity and mortality in kidney transplant recipients. Patients are at risk of GI infections during 1-6 months after transplantation. The major viral pathogen involving GI tract in transplanted patients is CMV. The incidence of active disease in seropositive patients is about 25%. There is a significant increase in mortality of kidney recipients suffering GI disease with CMV. Case: A 58-year-old man hospitalized with weakness and confusion three weeks after kidney transplantation. Gradually LLQ (Left lower quadrants) tenderness appeared. Abdominal X-ray showed subdiaphragmatic air. Sigmoidal perforation was revealed after abdominal laparotomy. CMV-PCR (Polymerase chain reaction) from blood was positive and CMV colitis was confirmed by colonic biopsy. Ganciclovir and broad-spectrum antibiotics were started but he died 5 days later because of sepsis. Conclusion: CMV disease may be fatal in kidney recipients. Despite severe disease, there may be just a few signs and symptoms. So, there must be a high index of suspicion in kidney recipients during first 6 months after transplantation. |
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| Keywords: Cytomegalovirus, Colitis, Colonic perforation, Transplantation |
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Full-Text [PDF 221 kb]
(3720 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/05/31 | Published: 2014/05/31
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