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Anti-nociceptive effects of the aqueous extracts of Portulaca Oleracea seeds in mice
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H Miladi Gorgi *   , A Rashidi Pour , R Ghorbani |
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Abstract: (9278 Views) |
| Background and objective: Portulaca oleracea (PO) overgrows in the different parts of Iran, that is used there as both a salad green and a medicinal plant. In previous studies, a 10% ethanolic extracts of the aerial parts (Leaf and stem) of PO showed anti-nociceptive activity in mice and rats. This study was designed to evaluate anti-nociceptive effects of different doses of the aqueous decoction extracts of PO (Seed). Methods: In this study, 65 male mice (25-30 gr) in model tail flick were used. Different doses of the extract 25, 50, 75, 100 mg/kg (IP) were injected to the separated groups of four (Test group) and water (10 ml/kg-IP) was injected to the one control group. The anti-nociceptive effect was determined 15 and 30 min after injection (N=15 mice for pilot study). Findings: The results showed that there was a significant difference between two groups (P<0.05), but the animals of test groups did not show significant difference in different doses and time. Conclusion: It is concluded that the aqueous extract of PO has anti-nociceptive activity, which is not related to dose and time. |
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| Keywords: Portulaca oleracea (Seed), Anti-nociception, Tail flick |
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Full-Text [PDF 274 kb]
(2154 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/05/31 | Published: 2014/05/31
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