|
The Association between Nutritional Factors during Infancy and Childhood and the Onset and Severity of Symptoms in Patients with Celiac Disease
|
S Azimzadeh    , R Zarrin , P Ayremlou , M Pashaei * , S Ahmadpour |
| 3.Department of Internal Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, I.R.Iran. , dr.pashaei@yahoo.com |
|
|
Abstract: (189 Views) |
Background and Objective: Celiac disease (CD), which is caused by an inappropriate immune response to the dietary protein gluten found in wheat, barley, and rye, is very rare in children, and most of the cases remain undiagnosed until later in childhood, often after the age of 10. The present study was conducted to determine the association between nutritional factors during infancy, the age of CD diagnosis, and the severity of disease manifestations in patients referred to Imam Khomeini Hospital in Urmia.
Methods: This cross-sectional study was conducted on 120 patients with CD referred to Imam Khomeini Hospital in Urmia. Demographic information, clinical symptoms of the patients, information related to the time of onset and diagnosis of the disease, and disease severity were extracted and examined using a questionnaire.
Findings: The mean age of the patients was 22.1±6.2 years and the mean age of onset of the disease was 17.7±7.2 years. 60% of the patients were breastfed for 24 months and 23.3% for 18 months. The time to initiate complementary feeding in 70.8% of the patients was at 6 months of age, of which 51.7% used cow's milk and formula milk and 17.5% used broth. 53.3% of the patients were breastfed and 46.7% used formula milk. The results of this study showed that the total severity of CD symptoms in patients who were breastfed for 3 to 24 months increased from 3 to 72, respectively (p<0.001). The total severity of symptoms in patients was reported to be 23 and 25 in the age range of 5-10 years and 26-30 years, respectively (p<0.001). The total severity of symptoms in patients whose complementary feeding was initiated at 5 months of age was 3 and at 6 months of age was 85 (p<0.001). A significant relationship was observed between the type of complementary feeding after infancy and the total severity of CD symptoms, and patients whose complementary feeding was cow's milk and broth showed a higher total severity of CD symptoms (total severity of CD symptoms was 4 for complementary feeding with pudding and 4 for complementary feeding with cow's milk and broth) (p=0.024).
Conclusion: The results of this study demonstrate a significant association between the age of onset of the disease, duration of breastfeeding, time to initiate complementary feeding, and type of complementary feeding with the severity of CD symptoms during infancy and childhood and thereafter. |
|
| Keywords: Celiac, Breast Milk, Gluten, Nutrition, Infant. |
|
|
Full-Text [PDF 284 kb]
(34 Downloads)
|
Type of Study: Research |
Subject:
Internal (Digestive)
Received: 2024/09/17 | Accepted: 2025/01/27 | Published: 2025/12/10
|
|
|
|
|
|
|
| Send email to the article author |
|
|
