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The Effect of High-Dose Vitamin D3 on Hemoglobin Levels in Dialysis Patients
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S Salarian    , S Ghasemi , S Ataei Azimi , M Javadi , M Gharehbeglou , J Ordoni Avval * , T Sabaghian , A Ahmadi Koomleh , SM Nasir-al-din Tabatabaei |
| 5.Department of Anesthesiology and Critical Care Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, I.R.Iran. , mzaj_ordoni@yahoo.com |
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Abstract: (575 Views) |
Background and Objective: Hemoglobin levels are crucial for infection control in dialysis units. Given the role of vitamin D in reducing anemia in dialysis patients, this study was conducted to investigate the effect of high doses of vitamin D3 on hemoglobin levels in dialysis patients.
Methods: This cross-sectional study was conducted on 33 dialysis patients hospitalized at Shohada Gomnam Hospital in Tehran. After initial assessment of demographic information, hemoglobin concentration, vitamin D3 levels, and other clinical indicators, the patients were divided into two groups: control (n=18) and intervention (n=15). The intervention group received intramuscular injection of 5 μg of vitamin D3 every week for four weeks, while the control group was given placebo. One month after the final dose, changes in vitamin D3 levels, hemoglobin, and other blood factors were measured and compared in the two groups.
Findings: The mean age of patients in the intervention group was 51.53±18.52 years and the control group was 50.83±13.30 years. The mean hemoglobin level in the intervention group increased from 9.22±0.94 mg/dL to 11.37±0.70 mg/dL (p=0.011). Other variables including Kt/v, MCV, creatinine, BUN, calcium, phosphorus, albumin, serum iron, TIBC, ferritin and CRP did not differ significantly between the two groups. Ferritin level increased from 268.13±170.34 to 385.07±159.52, while PTH level decreased.
Conclusion: The results of the study showed that high-dose vitamin D3 administration can improve hemoglobin levels and other blood factors in dialysis patients. Therefore, vitamin D3 can be used as an effective supplement for managing anemia in dialysis patients. |
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| Keywords: Vitamin D3, Hemoglobin, Anemia, Dialysis, Vitamin D Deficiency. |
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Full-Text [PDF 396 kb]
(93 Downloads)
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Type of Study: Research |
Subject:
Anesthesia
Received: 2024/08/12 | Accepted: 2024/10/29 | Published: 2025/11/8
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