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Effect of High-Dose Vitamin D3 on Hemoglobin Levels in Dialysis Patients
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S Salarian    , S Ghasemi , S Ataei Azimi , M Javadi , M Gharehbeglou , J Ordoni Avval * , T Sabaghian , A Ahmadi Koomleh , SM Nasir-al-din Tabatabaei |
| 5.Department of Anesthesiology and Critical Care Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, I.R.Iran. , mzaj_ordoni@yahoo.com |
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Abstract: (15 Views) |
Background and Objective: Hemoglobin level is critical for infection control in dialysis units. Considering the role of vitamin D in reducing anemia in dialysis patients, this study was conducted to evaluate the effect of high doses of vitamin D3 on hemoglobin levels in patients undergoing dialysis.
Methods: This cross-sectional study was performed on 33 dialysis patients admitted to Shahid Gomnam Hospital in Tehran. After initial assessment of demographic information, hemoglobin concentration, vitamin D3 levels, and other clinical indices, patients were divided into two groups: control (18 patients) and intervention (15 patients). The intervention group received 5 micrograms of intramuscular vitamin D3 weekly for four weeks, while the control group was given a placebo. One month after the last dose, changes in vitamin D3 levels, hemoglobin, and other blood factors were measured and compared between the two groups.
Findings: The mean age of patients in the intervention group was 53.51±18.52 years, and in the control group, 50.83±13.30 years. The mean hemoglobin level in the intervention group increased from 9.22±0.94 mg/dL to 11.37±0.70 mg/dL (p=0.011). Other variables, including Kt/v, MCV, creatinine, BUN, calcium, phosphorus, albumin, serum iron, TIBC, ferritin, and CRP, showed no significant differences between the two groups. Ferritin levels increased from 268.13±170.34 to 385.07±159.52, while PTH levels decreased.
Conclusion: The results of this study demonstrated that administration of high-dose vitamin D3 can improve hemoglobin levels and other blood factors in dialysis patients. Therefore, vitamin D3 may be considered an effective supplement for managing anemia in patients undergoing dialysis. |
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| Keywords: Vitamin D3, Hemoglobin, Anemia, Dialysis, Vitamin D Deficiency. |
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Type of Study: Research |
Subject:
Anesthesia
Received: 2024/08/12 | Accepted: 2024/10/29
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