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Comparison of the Effect of a Course of Endurance and Resistance Training Along with Sumac Supplementation on the Serum Levels of SIRT3, SIRT4 and AMPK in Alzheimer's Rats
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R Amini    , A Saremi * , MR Afarinesh |
| 2.Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, I.R.Iran. , a-saremi@araku.ac.ir |
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Abstract: (211 Views) |
Background and Objective: Alzheimer's disease is the most common type of dementia, which is associated with progressive memory loss. Given that free radicals and sirtuins are factors involved in the occurrence of Alzheimer's, the aim of the study was to compare the effect of 12 weeks of endurance and resistance training along with sumac intake on the serum levels of SIR3, SIR4 and AMPK in Alzheimer's rats.
Methods: In this experimental study, 49 mice aged 8-10 weeks and weighing 200±30 grams were randomly divided into seven equal groups, including: 1. healthy control, 2. Alzheimer's disease, 3. Alzheimer's disease by consuming sumac supplement, 4. Alzheimer's by performing endurance exercise, 5. Alzheimer's by doing endurance exercise and taking sumac supplement, 6. Alzheimer's by performing resistance training and 7. Alzheimer's patients were divided by doing resistance exercise and taking sumac supplement. Then, trimethyltin chloride was injected intraperitoneally to induce Alzheimer's disease. Maze test was used to measure memory. Sumac was added to the food of the samples at a rate of ten percent and was freely available to them. Endurance training of swimming in a special pool for rats and resistance in the form of climbing with weights attached to the rats' tails from a ladder was performed for 12 weeks. Then, serum levels of SIR3, SIR4 and AMPK were evaluated by ELISA method. Data were analyzed by SPSS software (p<0.05).
Findings: 12 weeks of endurance training significantly increased the amount of SIR3 (0.87±0.18) (p<0.002) and SIR4 (0.86±0.08) (p<0.001) in Alzheimer's group with endurance training, compared to Alzheimer's group; But there was no significant effect on AMPK (4.66±0.13). 12 weeks of resistance training increased the amount of SIR3 (0.77±0.14) (p<0.036) and SIR4 (0.80±0.08) (p<0.029) in Alzheimer's group with resistance training, compared to the group became Alzheimer's; But there was no significant effect on AMPK (4.0±40.24). Adding sumac to the endurance exercise program has a significant effect on the amount of SIR3 (0.90±0.13) and SIR4 (0.89±0.11) in the Alzheimer group with endurance exercise. Compared to the Alzheimer's group; But in AMPK (6.30±0.99) (p<0.05) had a significant effect. Adding sumac to the resistance exercise program caused significant changes in the amount of SIR3 (0.77±0.11) and SIR4 (0.86±0.15) in Alzheimer's group with resistance exercise. Compared to the Alzheimer's group; But in AMPK (5.93±1.32) (p<0.04) was significant.
Conclusion: Both endurance and resistance exercises caused a significant increase in SIR3 and SIR4 levels. Adding sumac to the endurance or resistance training program did not have a significant effect on SIR3 and SIR4; But in AMPK; both exercises; had a significant effect. |
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| Keywords: Endurance Training, Resistance Training, Rhus, Sirtuins, Adenosine Monophosphate Kinase. |
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Type of Study: Experimental |
Subject:
Sport Physiology
Received: 2024/07/3 | Accepted: 2024/11/2
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