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Comparing the Effects of a Course of Endurance and Resistance Training Combined with Sumac Supplementation on Serum Levels of SIRT3, SIRT4, and AMPK in a Rat Model of Alzheimer's Disease
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R Amini    , A Saremi * , MR Afarinesh |
| 2.Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, I.R.Iran. , a-saremi@araku.ac.ir |
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Abstract: (409 Views) |
Background and Objective: Alzheimer's disease (AD) is the most common type of dementia that is progressively associated with memory loss. Given that free radicals and sirtuins are factors involved in the occurrence of AD, the aim of this study was to compare the effect of 12 weeks of endurance and resistance training combined with sumac supplementation on serum levels of SIR3, SIR4, and AMPK in AD-induced rats.
Methods: In this experimental study, 49 rats aged 8-10 weeks and weighing 200±30 g were randomly divided into seven groups of 7, including healthy control group, AD-induced rats, AD-induced rats under sumac supplement, AD-induced rats under endurance training, AD-induced rats under endurance training and sumac supplement, AD-induced rats under resistance training, and AD-induced rats under resistance training and sumac supplement. Trimethyltin chloride was used intraperitoneally to induce AD. The maze test was used to measure memory. Sumac was added to the food of the samples at a ratio of 10% and was freely available to them. Endurance training was performed by swimming in a special mouse pool and resistance training by climbing a ladder with weights attached to the tails of the rats for 12 weeks. Then, serum levels of SIR3, SIR4, and AMPK were evaluated and compared by ELISA.
Findings: Twelve weeks of endurance training significantly increased SIR3 (0.87±0.18) (p<0.002) and SIR4 (0.86±0.08) (p<0.001) in the AD-induced group under endurance training compared to the AD-induced group; but there was no significant effect on AMPK (4.66±0.13). Twelve weeks of resistance training significantly increased SIR3 (0.77±0.14) (p<0.036) and SIR4 (0.80±0.08) (p<0.029) in the AD-induced group under resistance training compared to the AD-induced group; but there was no significant effect on AMPK (4.40±0.24). Adding sumac to the endurance training program did not have a significant effect on the levels of SIR3 (0.90±0.13) and SIR4 (0.89±0.11) in the AD-induced group under endurance training compared to the AD-induced group; but there was a significant effect on AMPK (0.99±0.30) (p<0.05). Adding sumac to the resistance training program did not cause significant changes in the levels of SIR3 (0.77±0.11) and SIR4 (0.86±0.15) in the AD-induced group under resistance training compared to the AD-induced group; but there was a significant effect on AMPK (5.93±1.32) (p<0.04).
Conclusion: The results of the study showed that both endurance and resistance training significantly increased the levels of SIR3 and SIR4, and adding sumac to the endurance or resistance training program had no significant effect on the levels of SIR3 and SIR4; however, both exercises had a significant effect on AMPK. |
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| Keywords: Alzheimer's Disease, Endurance Training, Resistance Training, Sumac, Sirtuin, Adenosine Monophosphate Kinase. |
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Full-Text [PDF 440 kb]
(33 Downloads)
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Type of Study: Experimental |
Subject:
Sport Physiology
Received: 2024/07/3 | Accepted: 2024/11/2 | Published: 2025/10/18
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