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Comparison of Immunohistochemical Expression of Oct4 in Oral and Cutaneous Squamous Cell Carcinoma
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R Gorgani Firuzjaee    , M Seyedmajidi * , Gh Kamrani , S Seyedmajidi |
| 2.Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , ms_majidi79@yahoo.com |
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Abstract: (111 Views) |
Background and Objective: Oral squamous cell carcinoma (OSCC) is the most common oral cancer in the world, and cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Oct4 acts as a master regulator for self-renewal in cancer stem cells and regulation of proliferation. The aim of the present study was to compare the immunohistochemical expression of Oct4 in OSCC and CSCC according to the different biological behavior of these two lesions.
Methods: In this cross sectional study, immunohistochemical staining for Oct4 was performed on 60 paraffined blocks (30 cases of OSCC and 30 cases of CSCC). Clinical information in the cases of OSCC were extracted from the patients’ record. The expression of Oct4 was graded according to the percentage of stained cells and the intensity of staining.
Findings: 63.3% of OSCC lesions and 56.7% of CSCC lesions had more than 50% staining, and the difference between them was not significant (p=0.718). OSCC and CSCC were not different in terms of intensity of staining and staining percentage of tumoral cells and final score. Correlation between tumor differentiation, clinical stage, lymph node involvement and location of lesion with Oct4 expression in OSCC patients were not seen. In CSCC, tumor differentiation and location of lesion were not related to Oct4 expression.
Conclusion: The results of the present study showed that Oct4 probably cannot be a suitable marker to indicate the different clinical behavior of OSCC and CSCC but the high expression of Oct4 in a high percentage of OSCC and CSCC samples supports the oncofetal role of this marker in the mentioned lesions. |
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| Keywords: Carcinoma, Squamous Cell, Neoplasm Metastasis, Prognosis, Octamer Transcription Factor-4. |
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Type of Study: Research |
Subject:
Dentistry (Pathology)
Received: 2024/04/14 | Accepted: 2024/08/10
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