|
Comparison of Immunohistochemical Expression of Oct4 in Oral and Cutaneous Squamous Cell Carcinoma
|
R Gorgani Firuzjaee    , M Seyedmajidi * , Gh Kamrani , S Seyedmajidi |
| 2.Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , ms_majidi79@yahoo.com |
|
|
Abstract: (426 Views) |
Background and Objective: Oral squamous cell carcinoma (OSCC) is the most common oral cancer in the world, and cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Oct4 acts as a master regulator for self-renewal ability and in cancer stem cells and regulates tumor proliferation. The present study was conducted to compare the immunohistochemical expression of Oct4 in OSCC and CSCC, considering the different biological behavior of these two lesions.
Methods: In this cross-sectional study, immunohistochemical staining for Oct4 was performed on 60 paraffin-embedded blocks (30 OSCC and 30 CSCC). Clinical information was extracted from the patients' medical records. Oct4 expression was graded and compared according to the percentage of stained cells and the staining intensity of cells and their sum.
Findings: In this study, 63.3% of OSCC lesions and 56.7% of CSCC lesions had staining above 50%, and the difference between them was not significant. The two types of lesions did not differ in terms of staining intensity, percentage of tumoral cells staining, and final score. There was no association between Oct4 expression and lesion differentiation, clinical stage, lymph node involvement, and lesion location in OSCC patients. In CSCC patients, tumor differentiation and lesion location were also not associated with Oct4 expression.
Conclusion: The results of the present study showed that Oct4 may not be a suitable marker to explain the different clinical behavior of OSCC and CSCC, but the high expression of Oct4 in a high percentage of OSCC and CSCC samples supports the oncofetal role of this marker in these lesions. |
|
| Keywords: Squamous Cell Carcinoma, Metastasis, Prognosis, Transcription Factor Oct4. |
|
|
Full-Text [PDF 476 kb]
(49 Downloads)
|
Type of Study: Research |
Subject:
Dentistry (Pathology)
Received: 2024/04/14 | Accepted: 2024/08/10 | Published: 2025/08/11
|
|
|
|
|
|
|
| Send email to the article author |
|
|
