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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 18, Issue 7 (7-2016) ::
J Babol Univ Med Sci. 2016; Volume 18 Back to browse issues page
The Effect of Hydroalcohlic Vac Extract on Pituitary-Thyroid Axis Function in Adult Male Rats
Z Hashempour , E Hosseini *
Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, I.R.Iran , ebrahim.hossini@yahoo.com
Abstract:   (7484 Views)

BACKGROUND AND OBJECTIVE: Thyroid disorders are relatively common diseases throughout the world. According to chemical drugs side effects, this study aimed to investigate the effect of the pituitary-thyroid axis function VAC extract in adult male rats.

METHODS: In this study, 50 adult male rats were divided into control and experimental groups received doses of 50, 100 and 200 mg / kg VAC extracts. All prescribed for 30 days and was conducted by gavage. In the end, after collecting blood samples from animals to measure T3, T4 and TSH hormones, thyroid removed and after preparing tissue sections follicles were counted and compared.

FINDINGS: The results showed that extracts of Vitex decreased TSH and increased T4 hormone in the order of 0.72±0.1 and 3.66±0.30 in the control group to 0.27±0.03 and 5.76±0.47 in the group receiving dose of 200 mg/kg and increases T3 of 71.20 ± 4.05 in control group to 90.60±5.63 and 88.8±5.39 at doses of 100 and 200 mg/kg. In addition, extracts of Vitex decreased body weight of 310±4.5 in the control group to 286.66±13.95, 265.83±13.77 and 276.83±10.13 at doses 50, 100 and 200 mg/kg (p<0.05). Moreover, Vitex extract increased the total number of follicles of 17.19±2.44 in the control group to 31.54±2.9 and 34.66±1.5 and 36.77±3.45 and active follicles of 13.15±2.04 in the control group to 28.83±2.46, 28.77±2.98 and 34.38±2.84 in experimental groups (p<0.01).

CONCLUSION: The results of this study demonstrated that Vitex extract significantly increased thyroid hormones and reduced TSH and body weight

Keywords: Vitex, Triiodothyronine, Thyroxine, Thyrotropin, Thyroid Follicles
Full-Text [PDF 324 kb]   (2554 Downloads)    
Type of Study: Experimental | Subject: Physiology
Received: 2016/01/23 | Accepted: 2016/06/26 | Published: 2016/07/18
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Hashempour Z, Hosseini E. The Effect of Hydroalcohlic Vac Extract on Pituitary-Thyroid Axis Function in Adult Male Rats. J Babol Univ Med Sci 2016; 18 (7) :41-47
URL: http://jbums.org/article-1-5919-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 7 (7-2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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