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:: Volume 17, Issue 9 (9-2015) ::
J Babol Univ Med Sci. 2015; Volume 17 Back to browse issues page
The Effects of Fenugreek Seed Powder on Oxidant and Antioxidant Factors ‎in Male Rats with Acetaminophen-induced Liver Toxicity
A Mohammadzadeh , A Gol * , H Oloumi
, agol@mail.uk.ac.ir
Abstract:   (8008 Views)

BACKGROUND AND OBJECTIVE: Acetaminophen can induce liver damage via oxidative stress. This study aimed to evaluate the protective effects of fenugreek seed powder on oxidant and antioxidant factors in acetaminophen-induced liver toxicity.

METHODS: In this experimental study, 24 male Wistar rats, weighing 250-280 g, were divided into four groups: control, normal saline+fenugreek seed powder, acetaminophen and acetaminophen+fenugreek seed powder. After 24 h of fasting, groups Normal and Normal+ Fenugreek received normal saline and groups Acetaminophen and Acetaminophen + Fenugreek received 1000 mg/kg acetaminophen by gavage. After six hours, the normal saline and acetaminophen groups received normal saline, whereas the groups receiving normal saline+fenugreek powder and acetaminophen+fenugreek powder were administered 1000 mg/kg of fenugreek seed powder via gavage. Twelve hours after the second gavage, the rats were sacrificed and liver tissues were frozen and assessed.

FINDINGS: A decline in malondialdehyde and hydrogen peroxide levels was observed in group acetaminophen+fenugreek, compared to the acetaminophen group (0.2608±0.03 and 1.56±0.153 vs. 6.7±0.344 and 2.38±0.104 in acetaminophen groups p<0.001 and p<0.05, respectively). Also, the activities of peroxidase and catalase increased in these groups, compared to the acetaminophen groups (19.07± 3.366 and 1.174±0.242 vs. 8.108 ± 2.46 and 0.614±0.089 in acetaminophen groups, respectively).

CONCLUSION: The results of this study showed that fenugreek seeds could lead to reduced oxidative stress in acetaminophen-induced liver toxicity

Keywords: Acetaminophen, Fenugreek seeds, Liver, Oxidative stress, Rat
Full-Text [PDF 551 kb]   (6746 Downloads)    
Type of Study: Research | Subject: Pharmacology
Received: 2014/11/11 | Accepted: 2015/08/1 | Published: 2015/08/22
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Mohammadzadeh A, Gol A, Oloumi H. The Effects of Fenugreek Seed Powder on Oxidant and Antioxidant Factors ‎in Male Rats with Acetaminophen-induced Liver Toxicity. J Babol Univ Med Sci 2015; 17 (9) :44-51
URL: http://jbums.org/article-1-5133-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 9 (9-2015) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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