Disease Modifying Osteoarthritis Drugs
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B. Heidari (MD) * , B. Yousef Ghahari (MD) |
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Abstract: (10357 Views) |
ABSTRACT Osteoarthritis is a common disease and
a significant cause of disability in the elderly. Available treatment does not
affect the course of osteoarthritis but exerts only a symptomatic effect on
pain. Recently many drugs have been introduced with the aim of
chondroprotection. Among them glucosamine and chondroitin are the most common
drugs which have been used in several studies. Nevertheless, the results vary
across various studies. While a chondroprotective effect has been observed in
some studies, in a number of studies the effects of glucosamine or chondroitin
alone or in combination did not differ with placebo. Different drugs dosages,
duration of treatment, and treatment outcomes and study designs have been
considered the most important confounders affecting the results of various
studies as well as for explanation of the contradictory results. In addition,
in a number of studies, drugs such as diacerein, anti-osteoporotic medications,
soya bean, and tetracycline have shown chondroprotective potentials in
osteoarthritis. This review by comparing the results of available studies
provides a rational for prescription of these drugs in osteoarthritis. |
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Keywords: Osteoarthritis, Disease modifying, Glucosamine, Chondroprotection |
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Full-Text [PDF 419 kb]
(1767 Downloads)
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Type of Study: Research |
Subject:
Biochemical Received: 2013/03/9 | Accepted: 2013/07/10 | Published: 2014/08/9
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