[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Issue 4 (10-2010) ::
JBUMS 2010, 12(4): 14-20 Back to browse issues page
Effect of Ketamine in the Treatment of Patients with Major Depressive Disorder
F Kheirkhah *, AA Moghadamnia, G Tayebi, A Bijani, P Tayebi, A Salavati
Abstract:   (7774 Views)
BACKGROUND AND OBJECTIVE: Major depressive disorder is a common and destructive mental disorder with relatively long episodes, high tendency to be chronic and recurrence, and responsible for many physical and mental disabilities that has the lifetime prevalence of about 17% to 19%. With regard to the improvement of non responder patients to routine treatment following a single dose injection of ketamine, this study was done to investigate the effect of ketamine on patients with major depressive disorder (MDD).
METHODS: This clinical trial study (semi-experimental design) was performed on 60 patients with MDD according to DSM IV-TR criteria. A single intravenous dose of ketamine (0.5 mg/kg) was given to the patients. Depression level of all patients was assessed before injection, on the days 2 and 7 after injection of ketamine and at the end of 1st and 2nd months based on Beck and Hamilton Depression Scale. Criteria for response to treatment with ketamine was reduction of 50% or greater in Hamilton and Beck scores.
FINDINGS: The results showed that mean score for Hamilton test before injection, on the days 2 and 7 after injection was 28.71±9.12, 20.57±10.88 and 16.85±10.70, respectively and mean score for Beck test before injection, on the days 2 and 7 after injection was 32.28±13.96, 25.05±14.10 and 19.71±13.40, respectively that significantly decreased as compared to before injection (p<0.05). The results of the scores decreased over 50% in about 20% of patients on the second day and 40% on the seventh day after injection of ketamine. Improving symptoms of depression in these patients was not associated with other variables such as age, sex, marital status, residence place, education level and season of injection.
CONCLUSION: With regard to easy administration, rapid effect and appropriate duration of action of intravenous single dose of ketamine in patients with MDD, it can be a good alternative for acute phase treatment of major depression.
Keywords: Major depressive disorders, Mood disorders, Ketamine, NMDA receptor antagonist
Full-Text [PDF 205 kb]   (1982 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/06/6 | Published: 2014/06/6


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kheirkhah F, Moghadamnia A, Tayebi G, Bijani A, Tayebi P, Salavati A. Effect of Ketamine in the Treatment of Patients with Major Depressive Disorder. JBUMS. 2010; 12 (4) :14-20
URL: http://jbums.org/article-1-3662-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 12, Issue 4 (10-2010) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Persian site map - English site map - Created in 0.04 seconds with 32 queries by YEKTAWEB 4343