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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 1, Issue 3 (7-1999) ::
J Babol Univ Med Sci. 1999; Volume 1 Back to browse issues page
Chronic exposure to Lead and DNA, protein & ultrastructural changes in rat submandibular glands
M Abdollahi * , Gh Abri , M Sharif Zadeh , H Marzban , M Torab Jahromi
Abstract:   (8766 Views)
Objective: Structural changes of rat submandibular glands (SMG) after long-term treatment with lead were studied. Methods: After using various doses of lead (0.01%, 0.04%, 0.05%), SMGs were removed and homogenized for measurement of total protein, DNA, calcium and lead concentrations. Also ultrastructural examination of glands by electron microscopy (EM) was carried out. Findings: Total protein, DNA and intracellular calcium concentrations of treated glands at 0.04% and 0.05% lead concentrations showed significant reduction when compared with those of controls. Data of lead measurement as determined by atomic absorption spectroscopy showed that lead treatment resulted in accumulation of lead in rat’s SMGs. Lead treatment also caused degenerative changes in the cells. Dilation of rough endoplasmic reticulum (RER) and swollen mitochondria were observed in the (0.05%) treated group. Transformation and enlargement of mitochondria were also determined in the (0.04%) treated group. Conclusion: It is proposed that lead treatment can reduce exocytosis processes by the reduction in energy level of the cell and destruction of RER or mitochondria. Considering properties of lead to substitute for calcium in many intracellular events, different types of alterations may ensue, including interaction with protein and DNA synthesis. To elucidate the exact mechanisms of observed alterations further studies are needed to conduct.
Keywords: Lead, Chronic exposure, Submandibular glands, DNA, Protein, Structural changes
Full-Text [PDF 1567 kb]   (1706 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/05/25 | Published: 2014/05/25


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Abdollahi M, Abri G, sharif Zadeh M, Marzban H, Torab Jahromi M. Chronic exposure to Lead and DNA, protein & ultrastructural changes in rat submandibular glands. J Babol Univ Med Sci 1999; 1 (3) :29-36
URL: http://jbums.org/article-1-2948-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 1, Issue 3 (7-1999) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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