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Prevalence of anti HDV in HBV carriers in Babol during 2000-02
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MR Hassanjani Roshan *   , AA Baiki , MJ Soleimani |
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Abstract: (8156 Views) |
| Background and Objective: Hepatitis D virus is a defective RNA containing virus that only infects human in the presence of HBV either as a coinfection or as superinfection in HBV carriers. Hepatitis D may accelerate the progress of chronic HBV infection to chronic hepatitis, cirrhosis and hepatocellular carcinoma. More than 3% of population in our country is chronic HBV carriers. The aim of this study was to determine the prevalence of anti HDV in asymptomatic HBV carriers in Babol. Methods: This prospective study was performed on all HBV carriers who were diagnosed by Babol blood bank center and also their infected family members during 2000-2002. In all cases, anti HDV were assayed by Elisa. Proportions were compared by T-test, Chi-square and Fisher’s exact tests. Findings: From 546 cases of HBV carriers, 319 (58.4%) were male and 227 (41.6%) were female. 489 (89.6%) cases of anti HBe+ (Mean age±SD 32.13±11.9 years) and 57 (10.4%) cases of HbeAg+ (Mean age±SD 23.7±11.24 years) were studied. Anti HDV was positive in 6 (1.9%) of males and 5 (2.2%) of females (P=0.769). Anti HDV was positive in 7 (1.4%) cases of Anti HBe+ and 4 (7%) of HbeAg+ cases (P=0.02). in total, the prevalence of anti HDV was 2% in all patients. Conclusion: The results showed that HDV is endemic in our area and its prevalence is higher in HbeAg+ cases. The study of prevalence of anti HDV in high-risk groups is recommended. |
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| Keywords: HBV carriers, Hepatitis D, Anti HDV, Prevalence |
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Full-Text [PDF 272 kb]
(1701 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/05/31 | Published: 2014/05/31
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