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A Case Report of Response to Quetiapine Treatment in Neuropsychiatric Manifestations of Juvenile Huntington's Disease
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TMS Tengku Kamarulbahri *   , F Rahim |
| 1.Department of Psychiatry, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia. , drtgsaifuddin@gmail.com |
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Abstract: (46 Views) |
Background and Objective: Juvenile Huntington’s disease (JHD) represents a rare form of neurodegenerative genetic disorder characterized by potential neuropsychiatric symptoms. Within the broader spectrum of Huntington’s disease (HD), JHD cases constitute a relatively small subset. The importance of understanding JHD lies in its distinct clinical presentation, particularly the emergence of primary psychiatric symptoms during different phases of the disease. The purpose of this case report is to highlight the clinical manifestation and treatment outcome of a JHD patient, focusing on mood and behavioral changes following the initiation of Quetiapine treatment.
Case Report: The patient is an 18-year-old woman presented with prominent neurological and psychological symptoms including mood symptoms, self-harm, and suicidal attempts. Neurocognitive assessment using the Montreal Cognitive Assessment Test revealed impairment with a score of 17 out of 30. The patient had mild neurocognitive impairment due to JHD. Sodium valproate was initially prescribed, and due to the presence of mood symptoms, irritability, and behavioral problems, quetiapine was added to the treatment regimen, which resulted in significant improvement in the patient's mood. The patient was discharged with Quetiapine 150 mg and Epilim 600 mg once a night. During the two-week follow-up, the patient showed significant improvement in mood regulation and self-harm behaviors after starting Quetiapine.
Conclusion: The results of this case report emphasize the effectiveness of Quetiapine in improving mood, suicide attempt, and behavioral symptoms in JHD.
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| Keywords: Huntington's Disease, Suicide, Quetiapine. |
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Type of Study: case report |
Subject:
Psychiatry
Received: 2024/01/23 | Accepted: 2024/04/21
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