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The Effect of Aqueous Extract of Cinnamon on Anaerobic Peri-Implantitis Bacteria
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Kh Sahib Hasen *    , Gh Abdul-Hamid Naji , AR Jabur |
| 1.Department of Prosthodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq. , Khadija.Khreibet1908@codental.uobaghdad.edu.iq |
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Abstract: (1217 Views) |
Background and Objective: Even though dental implants have a high success rate, the most frequent implant dentistry problem is peri-implantitis. With increased bacterial resistance to antibiotic, the herbal products are more preferred. This study aimed to find a concentration of aqueous cinnamon extract that prevents the patient's anaerobic bacterial flora from growing with peri-implantitis and to evaluate the phytochemical composition of Aqueous Extract of cinnamon.
Methods: This experimental in vitro study was conducted using total anaerobic bacterial samples isolated from the implant pockets of 10 patients (male and female) aged 40-60 years suffering from chronic peri-implantation requiring the presence of a probing pocket depth≥10 mm and clinical attachment loss of (1-2) mm or more. Antibacterial assay was performed using well diffusion agar at an extract concentration of 5, 10, 12, 15, 20, and 25 mg/mL, which were chosen randomly according to the pilot study with a positive control as CH2% and a negative one as distilled water to measure the inhibition zone through the center from edge to edge of inhibition zone. Final concentrations (1, 3, 6, 12, 24, 48) mg of the extracts were used to find the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Secondary metabolites of the prepared cinnamon aqueous extract were detected using Gas Chromatography-Mass Spectrometry (GC-MS) and phytochemical test.
Findings: The present study showed that Cinnamon contains alkaloid, flavonoids, saponins, and glycoside, and it significantly inhibited the isolated bacteria with MBC at 24 mg/mL and Minimum Inhibitory Concentration (MIC) at 12 mg/mL. Well-diffusion assay revealed that the mean values of inhibition zone diameter were 1.15±0.118, 1.27±0.142, 1.38±0.132, 1.51±0.13 and 1.46±0.084 cm for concentrations of 12.5, 15, 20, 25 and Chlorhexidine (CHX) 2% mg/mL, respectively (p>0.05). The increase in inhibition zone diameters was associated with the increase in cinnamon extract concentration, while concentrations of (5.10) mg/mL revealed no zone of inhibition.
Conclusion: According to the results, this study determined that cinnamon was a potent antimicrobial agent, and that it can be used as anti-infective therapy against peri-implantitis to overcome implant failure. |
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| Keywords: Herbal Extract, Cinnamomum Aromaticum, MBC, MIC, Phytochemical, Dental Implant. |
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Full-Text [PDF 580 kb]
(142 Downloads)
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Type of Study: Research |
Subject:
Dentistry (Radiology)
Received: 2023/03/21 | Accepted: 2023/06/7 | Published: 2024/10/1
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