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Diagnostic Value of C-Reactive Protein and Interleukin-6 in Prevention of Negative Appendectomy
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H Layegh    , T Teimour Nezhad , MS SeyedSadeghi * |
| 1.Department of Surgery, School of Medicine ,Ardabil University of Medical Sciences ,Ardabil, I.R.Iran. , dr.mirsalimseyedsadeghi@gmail.com |
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Abstract: (893 Views) |
Background and Objective: Acute appendicitis is one of the common reasons for abdominal surgery in any age group, and most cases are rarely diagnosed, which causes unnecessary surgery (negative appendectomy). The aim of this study is to determine the diagnostic value of C-reactive protein (CRP) and interleukin-6 (IL-6) in the prevention of negative appendectomy.
Methods: This cross-sectional study was conducted on 208 patients with acute abdominal surgery and primary diagnosis of acute appendicitis at Fatemi Hospital in Ardabil in a period of 6 months. C-reactive protein (CRP) and interleukin-6 (IL-6) levels were measured before surgery in all patients. Patients were divided into positive and negative groups based on pathology results. Then the laboratory results were compared with histopathological findings after surgery.
Findings: The level of IL-6 in the positive group was 107.25±3.54 and in the negative group was 75.50±2.41, and the difference was statistically significant (p=0.032). The mean CRP was 35.5±12.1 in the positive group and 11.1±5.3 in the negative group (p<0.001). There was a statistically significant relationship between IL-6 in normal patients and IL-6 in positive patients with purulent (p=0.006) and gangrene (p<0.001) pathology. There was a significant relationship between IL-6 positive patients with follicular hyperplasia pathology and IL-6 positive patients with purulent and gangrene pathology (p<0.001). Moreover, there was a statistically significant relationship between IL-6 positive patients with inflammatory pathology response and IL-6 positive gangrene patients (p<0.001). Sensitivity, specificity, positive predictive value, negative predictive value for IL-6 were 83, 88, 86, 79 and for CRP were 83, 85, 89, 81, respectively.
Conclusion: The results of the study showed that the simultaneous measurement of CRP and IL-6 are useful biomarkers in the diagnosis and prevention of negative appendectomy.
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| Keywords: Appendicitis, Interleukin 6, C-Reactive Protein, Appendectomy. |
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Full-Text [PDF 282 kb]
(156 Downloads)
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Type of Study: Cross Sectional |
Subject:
surgery
Received: 2023/03/17 | Accepted: 2023/05/31 | Published: 2023/12/24
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