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Showing 9 results for Probiotic
M. Rafraf (phd), S. Nabavi (msc) , M.h. Somi (md), A. Homayouni-Rad (phd), M. Asghari-Jafarabadi Rad (phd),
Volume 16, Issue 9 (9-2014)
Abstract
BACKGROUND AND
OBJECTIVE: Probiotics have beneficial effects on
the host by improving the intestinal microflora. The role of intestinal
microflora in obesity-related disorders such as nonalcoholic fatty liver
disease (NAFLD) largely is known. There are evidences for the possible effects
of probiotics products in NAFLD. This study aimed to investigate the effects of
probiotic yogurt intake compared to conventional yogurt on anthropometric
parameters in patients with NAFLD. METHODS: In
present double-blind randomized controlled clinical trial, 72 NAFLD patients with
body mass index (BMI) greater than 25 Kg/m2 were studied. Subjects
were randomly allocated to either the intervention or control group (n=36, in
each group) and consumed daily 300 g of probiotic yogurt or 300 g of
conventional yogurt for 8 week, respectively. Dietary intakes, weight, height
and waist circumference were measured at the beginning and end of the study and
BMI were calculated. Statistical analysis was performed using SPSS software.
Data were analyzed by chi-squared test, independent sample t-tests, analysis of
covariance and paired t-tests. (IRCT: 201210313664N8) FINDINGS: In
probiotic yogurt group significant reductions were observed in weigh
(84.32±13.2 vs. 82.58±13.33 Kg) and BMI (30.1±3.61 vs. 29.48±3.7 Kg/m2
p<0.001 for both). Changes percent in weight and BMI were 1.07% compared
with the control group (p<0.004 and p<0.005, respectively). Waist
circumference significantly was decreased in both of groups (97.4±8.45 vs.
95.71±8.36 cm in probiotic yogurt group and 98.38±10.58 vs. 97.04±10.56 cm in
conventional yogurt group p<0.002 for both) but these changes were not
different between two groups. CONCLUSION: The result of this
study showed that probiotic yogurt consumption lead to reduction of weight and BMI in
NAFLD patients and may be useful in weight management in these patients.
Z Akbarian-Rad, M Haghshenas Mojaveri, Y Zahedpasha, M Ahmadpour-Kacho, K Hajian Tileki, Y Taghipour,
Volume 17, Issue 5 (5-2015)
Abstract
BACKGROUND AND OBJECTIVE: Abdominal colic during infancy is a common complaint of parents within the first three months after the child’s birth. As the intestinal microflora in these infants is different from non-colic newborns, we aimed to determine the effects of probiotics on the balance of intestinal microflora and reducing restlessness in infants with colic.
METHODS: This randomized clinical trial was performed on 44 breastfed infants (20-60 days old), with a birth weight of > 2500 g, suffering from colic, based on Wessel’s definition. These infants received 1-5 drops of placebo (label 1) per day for five consecutive days. Afterwards, they were administered 2-5 drops of Lactobacillus reuteri (label2) (17938 DSM) per day for 14 consecutive days. The parents were contacted twice on a daily basis and the duration of cramps and restlessness in infants was recorded and evaluated (IRCT=2014012713489).
FINDINGS: Among 44 infants, 36 cases completed the study. The mean period of restlessness after 5 days of receiving placebo and L. reuteri was 275±142.8 and 172±88.3 min, respectively (p<0.001). Also, after 14 days of L. reuteri administration, the mean period of restlessness was 106±53.67 min.
CONCLUSION: The results showed that probiotic L. reuteri reduced crying and restlessness duration in infants
with colic.
D Jafarpour, Mm Jokari,
Volume 20, Issue 0 (3-2018)
Abstract
BACKGROUND AND OBJECTIVE: Recent industrial activities development has led to increase heavy metals released into atmosphere, water and soil. These metals, due to their toxicity nature replace essential metals present in connection positions, damage cells and cellular processes. Therefore, in this review article, the effect of probiotics on the ability to absorb and remove heavy metals was investigated
Materials and Methods: The research was carried out with the keywords of heavy metals, probiotics and the results of the studies were expressed as follows.
Search by the keywords “Heavy Metals Probiotics” in databases Pubmed, Scopus and Web of Science were done and then 45 related articles that published in 2000-2017 were selected.
Findings: Microorganisms having reciprocal strategy prevents elements changing to less harmful materials through inter- or intracellular connection from undesirable reactions in the host cells. In addition they are capable to exit metals from cell cytosol. Probiotics have indicated that through attaching to heavy metals can protect host from their absorption. Probiotics protect host from their poisonous effects through three mechanisms including: ionic exchange reaction to peptidoglycan, deposition through nuclear reactions and combining to oxygen and nitrogen ligands to attached heavy metals.
Conclusion: Biodegradability in which microbes used to detoxification and degeneration bio-environmental pollutants is a suitable option to replace present physic-chemical strategies to remove heavy metals. Therefore, based on probiotics potential in bio absorption and heavy metals removal, it is recommended to use them to reduce heavy metals toxicity.
E Lashani, A Davoodabadi, Mm Soltan Dallal,
Volume 20, Issue 3 (3-2018)
Abstract
BACKGROUND AND OBJECTIVE: Lactobacilli are gram positive, catalase-negative, and found in a variety of fermented foods such as honey, as well as human normal flora. The aim of this study was to identify lactobacillus Plantarum and lactobacillus Paracasei in Iranian honey samples and to investigate the probiotic and antimicrobial properties of them against Staphylococcus aureus.
METHODS: This cross-sectional study investigated 88 honey samples from different areas in Iran at 6 months, from May to September, 2016. Samples were cultured in MRS broth and after were cultured on MRS agar. Sequencing of 16S rDNA gene was used to detect lactobacillus isolates. Then probiotic capacity (acid and bile resistance) of isolates was measured. Antimicrobial activity of lactobacillus isolates was investigated by diffusion method from wells and antibiotic resistance by disc diffusion method.
FINDINGS: From 88 honey samples, 39 Lactobacillus isolates were isolated, four L. plantarum and two L. paracasei were identified by molecular technique. Every six isolates tolerated acidity but were sensitive to bile salt. Five isolates inhibited the growth of S. aureus. The most antibiotic resistance of Lactobacillus strains was seen to vancomycin(100%), nalidixic acid(100%) and streptomycin(100%).
CONCLUSION: Iranian honey samples can be a source for different Lactobacillus species as L. plantarum and L. Paracasei which some of these species could have wonderful inhibitory effects against pathogen bacteria like S. aureus.
S Sadeghi, F Jaberi Ansari, H Jalili,
Volume 20, Issue 6 (6-2018)
Abstract
BACKGROUND AND OBJECTIVE: Probiotics are living microorganisms whose adequate intake has shown healthful effects in the host body and have been suggested to have beneficial effects in the prevention and treatment of many diseases. This study was conducted to investigate the obstacles and challenges of probiotic products in the production process and their effects on human health.
METHODS: For data collection in this review article, articles containing one of the terms “probiotic”, “lactobacillus”, “bifidobacterium”, “biogenic amine” and “antibiotic resistance” from 1990 to 2017 were searched and reviewed at Thomson Reuters, Pubmed, Scopus, Science Direct and Islamic World Science Citation Center(ISC).
FINDING: Research has shown that systematic infections and chronic diseases, over-stimulation of the immune system, transfer of antibiotic resistance genes, production of biogenic amines and D-lactic acidosis, lack of survival and sustainability of microorganisms and ultimately the change in the taste and flavor of probiotic products are among the obstacles and challenges facing the production of probiotics. The use of bifidobacterium to transfer antibiotic resistance genes is safer than other microorganisms for the production of probiotic products.
CONCLUSION: Based on the results of this study, probiotics are only safe in healthy people, although they are very useful for human health, but their use in children, pregnant women and people with a weakened immune system causes infection.
Maryam Koopaie, Sana Jahangir, Ronak Bakhtiari,
Volume 20, Issue 9 (9-2018)
Abstract
BACKGROUND AND OBJECTIVE: Consumption of food causes changes in oral flora. Foods that create an appropriate media for Streptococcus mutans and other cariogenic microflora, cause increase the rate of tooth caries. The aim of this study was the assessment of short-term consumption of probiotic cake (contain Bacillus coagulans) on salivary streptococcus mutans count and comparison with ordinary cake.
METHODS: A cross over blind study was conducted on 30 healthy adult volunteers in two groups (16 males and 14 females). The first group ate probiotic cake (75 grams daily) for 1 week and after 2 weeks wash out period, they ate ordinary cake. The second group first ate ordinary cake and after 2 weeks wash out period, they ate probiotic cake (75 grams daily). Non-stimulating salivary samples, before (as baseline) and after eating probiotic and ordinary cake, were collected. Then counting of streptococcus mutans was done with colony counter.
FINDINGS: Of the 30 patients, 16 (53.33%) were male and 14 (46.67%) were female with an average age of 40.86±17.15 years. Number of Streptococcus mutans in baseline saliva samples was (7.872±1.430)106 CFU/ml and in the saliva samples after consumption of probiotic cake was (4.652±0.841)106 CFU/ml and in saliva samples after consumption of ordinary cake was (21.386±3.895)106 CFU/ml. There was no significantly difference between mutants count before and after eating probiotic cake (p=0.769) but after consumption of ordinary cake than probiotic cake the count of streptococcus increased significantly (21.3±39.9 compared with 4.65±0.84) (p=0.032).
CONCLUSION: Based on the results of this study, the addition of probiotic bacteria to sweet and high-consumption foods can reduce the adverse effects of foods such as cakes on oral health.
A Pegah, I Khodadadi, F Mirzaei, H Tayebinia, E Abbasi,
Volume 23, Issue 1 (3-2021)
Abstract
BACKGROUND AND OBJECTIVE: The main and effective treatment for diabetes is the use of insulin and synthetic drugs and herbal medicines, which may be accompanied by several side effects. Given that GLP-1 secretion is reduced in diabetic patients compared to healthy individuals, the aim of this study was to determine the simultaneous effect of resveratrol and probiotics on insulin secretion and glucagon-like peptide (GLP-1) and to evaluate insulin resistance in diabetic rats.
METHODS: In this experimental study, 40 adult male Wistar rats weighing approximately 250-300 g were used. Animals were randomly divided into 5 groups: control group, diabetic group (using 65 mg/kg streptozotocin and 110 mg/kg nicotinamide intraperitoneally), diabetic group treated with probiotics (50×109 bacteria/kg body wt−1 daily by dissolving in water), diabetic group treated with resveratrol (10 mg/kg by gavage method) and diabetic group treated with probiotics and resveratrol (co-administration group). After four weeks, the animals were sacrificed and pancreatic tissue and blood samples were isolated for histopathological tests and biochemical tests. Blood glucose, insulin resistance, pancreatic GLP-1 as well as pancreatic histopathology were assessed.
FINDINGS: The co-administration group compared with the diabetic group caused a 42% reduction in serum glucose levels (p<0.001) and a 30% reduction in insulin resistance (p<0.001). The co-administration group also caused a 23.5% increase in insulin levels (p<0.001) and an 88% increase in GLP-1 (p<0.05). The co-administration group improved the histology of the pancreas.
CONCLUSION: The results of the study showed that resveratrol and probiotics are effective in controlling diabetes by increasing the levels of GLP-1 and insulin and decreasing insulin resistance.
N Mohitmafi , T Farrokhnia , P Olyaee , S Kalantari , Ss Seyyed Afsari ,
Volume 25, Issue 1 (3-2023)
Abstract
Background and Objective: Oral candidiasis is one of the most common oral manifestations of acquired immunodeficiency syndrome (AIDS). This condition affects the patients’ quality of life. This study aims to assess the effect of probiotic dietary supplements on oral Candida albicans (C. albicans) colonization in AIDS patients.
Methods: This randomized clinical trial was conducted on 30 AIDS patients with less than 100 CD4 cells per mm3, who were under anti-retroviral therapy. The patients were then randomly divided into two groups of intervention and control (n=15), based on their medical file number (even, odd). The intervention group received probiotic tablets (2 tablets/day for 1 month) along with anti-retroviral therapy (ART). The control group only received ART. One mL of saliva was collected from each patient on the first day of study and after intervention and was cultured on Sabouraud dextrose agar to quantify the number of C. albicans colonies in colony forming units/milliliter (CFUs/mL).
Findings: The two groups were initially identical in terms of CD4 count. Nine patients were withdrawn from the control, and 8 patients from the intervention group. Thus, 13 patients were analyzed (4 females, 2 males in the control group, and 4 females, and 3 males in the intervention group). The C. albicans colony count was significantly higher in the test group before the intervention (CFUs/mL=47714±40372, p=0.038). The difference in C. albicans colony count was not significant between the two groups after the intervention. In the control group, the C. albicans colony count did not change significantly (7833±1722 before, 7666±2160 after) while in the intervention group, the number of C. albicans significantly decreased after the intervention (47714±40372 before, 14571±25683 after, p=0.02).
Conclusion: According to the results of this study, it appears that probiotic dietary supplements can decrease C. albicans colonization.
H Karkehabadi , A Rajabnia , A Pournajaf , E Khoshbin ,
Volume 26, Issue 0 (3-2024)
Abstract
Background and Objective: The growth of residual bacteria within dental root canals is one of the main causes of root canal treatment failure. As a probiotic with antimicrobial properties, Lactobacillus casei has the ability to inhibit pathogenic microorganisms. The aim of this study is to investigate the antibacterial and anti-biofilm effect of Lactobacillus casei probiotic supernatant alone and in combination with AH Plus sealer on Enterococcus faecalis.
Methods: Enterococcus faecalis strain ATCC 29212 and Lactobacillus casei strain ATCC 7469 were used in this experimental laboratory study. Enterococcus faecalis strain was revived in Brain Heart Infusion Broth (BHI BROTH) and Lactobacillus casei strain in De Man, Rogosa and Sharpe (MRS) Broth under anaerobic conditions. Then, Lactobacillus casei supernatant was prepared. Agar diffusion method was used to investigate the antibacterial properties of the supernatant of Lactobacillus casei and sealer separately and in combination with each other. Furthermore, the anti-biofilm effect of these materials was evaluated using the microtiter plate assay.
Findings: According to the results of this study, the mean non-growth halo diameter of Enterococcus faecalis in the presence of Lactobacillus casei supernatant, AH Plus sealer and their combination was 14.66±0.57, 17.16±1.04 and 27.33±1.25 in 24 hours, 14.16±1.04, 15.75±1.08 and 24.66±1.15 in 48 hours and 13.66±1.52, 14.5±1.32 and 24.33±0.76 mm in 72 hours, respectively. The inhibition percentage of Enterococcus faecalis biofilm formation after treatment with AH Plus sealer, Lactobacillus casei supernatant and their combination was 23%, 17% and 33%, respectively.
Conclusion: The results of this study showed that Lactobacillus casei supernatant and AH Plus sealer have antibacterial and anti-biofilm effects on Enterococcus faecalis. Moreover, the combination of Lactobacillus casei supernatant with AH Plus sealer strengthens these effects.
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