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Showing 2 results for Letrozole
M Zeinalzadeh, , M Esmailpour, T Nazari,
Volume 10, Issue 3 (8-2008)
Abstract
BACKGROUND AND OBJECTIVE: Clomiphene citrate is the first–line treatment in patients with ovulatory dysfunction, but it may be associated with side effects for example multiple follicles, multiple pregnancy and adverse effects on endometrial growth. Nowadays, it is considered to use letrozole for induction ovulation. The aim of this study was to compare letrozole with clomiphene citrate for ovulation induction, in patients with polycystic ovarian syndrome (PCOs).
METHODS: This clinical trial study was performed on 107 PCOs patients. They divided into two groups. Group one received 100mg clomiphene citrate (n=57) and group two received 5mg letrozole (n=50) daily on days 3-7 of their menstrual cycle. Human chorionic gonadotrplin (hCG) at a dose of 10000IU was administered when at least one mature follicle was observed. A single IUI was performed 34 hours later. Then size and number of mature follicles, ovulation rate, endometrial thickness and pregnancy rate was measured.
FINDINGS: The number and the size of mature follicles were similar between two groups. The pregnancy rate in letrozole was 6% higher than clomiphene group (20% vs. 14%) that did not show significant difference. Endometrial thickness in letrozole and clomiphene citrate group was 64% and 64.9%, respectively. 86% of patients developed mature follicle in letrozole group who all of them showed ovulation, but in 72% of patients in clomiphene citrate group was developed mature follicles.
CONCLUSION: Letrozole may be an acceptable alternative to clomiphene citrate for ovulation induction and pregnancy rate in PCOs patients.
M Mokhtari , S Sadeghi ,
Volume 25, Issue 1 (3-2023)
Abstract
Background and Objective: The need to perform an abortion in the first three months of pregnancy with an effective and safe drug therapy is more important than other methods. The purpose of this study is to compare the effects of letrozole and misoprostol versus misoprostol alone on abortion.
Methods: In this clinical trial, 114 candidates for legal abortion in the first trimester of pregnancy were randomly assigned to three groups of 38 people receiving sublingual misoprostol alone with placebo (same amount of letrozole), misoprostol with letrozole 10 mg daily for 3 days and the third group was given misoprostol along with letrozole with a daily dose of 5 mg for 3 days. In addition to the demographic and obstetrical information of the patients, the primary outcome including complete and incomplete abortion, misoprostol dosage and side effects were compared in patients of three groups.
Findings: The mean gestational age of the patients was 73.1±9.2 days. A total of 84 (73.7%) patients had complete abortion, including 28 patients (73.7%) in the letrozole 5 mg group, 32 patients (84.2%) in the letrozole 10 mg group, and 24 patients (63.2%) were in the placebo group. In the letrozole 10 mg group, with a statistically significant difference, the rate of complete abortion was higher in them than in the placebo group (84.2 vs. 63.2%, p=0.037). 20 patients in the letrozole 5 mg group, 16 in the letrozole 10 mg group, and all patients in the placebo group received misoprostol, and the difference between the two groups of letrozole 10 mg and placebo was significant in terms of misoprostol intake (p=0.001). The most common side effect in patients of all three groups was nausea and vomiting, which did not have a statistically significant difference between all three groups.
Conclusion: The findings of the present study showed that letrozole 10 mg along with misoprostol is effective in patients who need legal abortion in the first trimester.
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