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Showing 7 results for fattahi
E Fattahi , Gh.a Jorsaraei , Aa Moghadamnia ,
Volume 15, Issue 3 (5-2013)
Abstract
ABSTRACT
BACKGROUND AND OBJECTIVE: Dursban is the most common organophosphate pesticides that used for control of pests. The main action of this compound is inhibition of cholinesterase enzyme, which adversely effects on reproductive system. Due to the use of pesticides in agriculture and the possible damage, the effect of this toxin on the sexual hormones and changes of testis tissue in mice was studied.
METHODS: In the experimental study, 40 adult male mice were divided into four equal groups including control, sham, experimental (1and 2) groups. In the experimental groups, animals were intraperitoneally injected with consecutive doses of 15mg/kg and 30mg/kg dursban for one month (five days per week). The olive oil was injected to sham group and control received no injection. Testes tissue sections were prepared to investigate possible changes occurring in the category of spermatogenic, Leydig cells and seminiferous tubule by eye piece (calibrated ocular lens). Diameter of testis was measured by micrometer. Levels of gonadotropin hormones and testosterone were assayed by radioimmunoassay. Then data were analyzed.
FINDINGS: Levels of gonadotropin hormones and testosterone in experimental (1 and 2) groups were significantly declined compared to control and sham group (p<0.05). The number of spermatogonia, primary and secondary spermatocyts, spermatids, Leydig cells, diameter of testis and seminiferous tubule diameter in the experimental (1 and 2) groups compared to control and sham group and also in the experimental 2 group compared to experimental 1 group were decreased (p<0.05).
CONCLUSION: These results demonstrated that dursban can cause the decrease of sexual hormones and damage of testes tissue that is pushing people toward infertility.
Ar Salehi Chaleshtori , F Fattahi, Ma Tabatabaiefar, A Hoseinipour, Hr Salehi Chaleshtori , F Rezaian, M Hashemzadeh Chaleshtori ,
Volume 16, Issue 1 (1-2014)
Abstract
BACKGROUND AND OBJECTIVE: Congenital hearing loss is the most common sensorineural defect in human. The most common genetic mutations in this disease are GJB2 mutations which are followed by SLC26A4 mutations. Following a report for the first time in the world insist on CABP2 gene interference in hearing loss production, the present study was launched to analyze this mutation in Iranian patients with hereditary hearing loss.
METHODS: This is a cross sectional study. Among samples with autosomal recessive familial hearing loss pattern, regarding pedigree and audiometric data 253 patients with moderate to profound hearing loss were selected and studied. The mutation c. 637+1G>T was investigated using PCR-RFLP method.
FINDINGS: PCR-RFLP findings revealed that c.637+1G>T mutation was absent in the deaf subjects with hereditary moderate to profound hearing loss in analyzed provinces.
CONCLUSION: The mutation c.637+1G>T in CABP2 gene does not play any role in the investigated Iranian subjects with hereditary hearing loss.
Esmail Fattahi, Mehdi Mousavi Moghadam, Ramzanali Khanbabaei,
Volume 17, Issue 2 (2-2015)
Abstract
ABSTRACT
BACKGROUND AND OBJECTIVE: Tricyclazole
is a systemic fungicide, used for eradicating rice blast disease. This
substance has replaced Hinozan pesticides and appears to have adversly effects
on reproductive tissues and hormone levels. Due to its widespread use in
agriculture, the effects of this toxin on testosterone changes and the
testicular structure of mice were evaluated in this study.
METHODS: In this experimental study, 30
adult male NMRI mice, weighing 33±3g, were selected and divided to equal three
groups: control, experimental 1, and experimental 2groups. The mice in
experimental groups 1 and 2 orally recieved 20 and 40 mg/kg of tricyclazole,
respectively for two weeks (5 consecutive days per week), while the control
group received no toxins. Twenty-four hours after the last injection, the mice
were killed with ether and then samples were taken from all groups. After
providing testicular tissue sections, different lines of spermatogenic cells,
Leydig cells, and the diameter of seminiferous tubules were measured, using a
eye piece. Testosterone level was measured via radioimmunoassay, and finally, the
obtained data were analyzed.
FINDINGS: Testosterone level was 1.26±0.44 ng/ml
in experimental group 1, 1.12±0.46 ng/ml in experimental group 2, and
0.16±0.059 ng/ml in the control group (p<0.05). The relative weight of the
testis, the diameter of seminiferous tubules, the number of Leydig cells, and
the number of blood vessels in experimental groups 1 and 2 significantly
increased, compared to the control group (p<0.05). Furthermore, the diameter
of the lumen area in group 2 (93.94±1.70 mm) showed a significant increase,
compared to the control grouop (82.32±1.71 mm) (p<0.05).
CONCLUSION: The
results indicated that tricyclazole toxin can impair testosterone secretion and
the testicular structure, leaving a adversly effect on sperm production system.
T Rowshanaie, M Sadoughi, E Fattahi,
Volume 17, Issue 7 (7-2015)
Abstract
BACKGROUND AND OBJECTIVE: Tricyclazoleis a popularTriazole pesticide used in agriculture to control rice blast disease.Due to thehigh consumption and stability of tricyclazole, as well as the digestive, nervous and hepaticdisorders it may cause, this study aimed to investigate the effects of tricyclazole on hepatic enzyme changes and tissue damagein the fetus of laboratory mice.
METHODS: Forthis experimental study, 30 mice (10 male, 20 female) with the age range of 10-12 weeks were purchased from Pasteur Institute, Northern branch, Iran. After mating and confirmation of pregnancy usinga vaginal plaque,the mice were randomly divided into three groups of control (N=6), experiment I(N=7) and experiment II (N=7). In the experimental groups, the mice received tricyclazole via intraperitoneal injectionat doses of 0.5 and1.5 mg/kg,respectively, whilethe control group received no toxins. All the animals were preservedunderoptimum conditions, and at day 17 of gestation, they were killed,and the fetuseswere removed from the body of the mothers. Sampling of hepatic tissues was performedto count fetal hepatocytes andevaluate tissuedamage. In addition, enzymelevels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase(ALP)were measured via the colorimetric method using theenzyme kit madeby Cayman company.
FINDINGS: In this study, microscopic evaluationsshowed a significant increase in the number of hepatocytes inexperimental group I (21.35 ± 0.85) and experimental group II (23.1±1.16) compared to the control group (16.9 ± 1.2)(P<0.05). Moreover, levels of ALTand AST were higher in the experimental groupscompared to the control group, whilethe level of ALP was observed to decrease in both groups (p<0.05).According to histopathological studies, concentrations of tricyclazole in the liver could lead to necrosis, inflammatory cell infiltration, hyperplasia, watery degeneration of hepatocytes and severe hepatomegaly.
CONCLUSION: According to the results of this study,enzymatic changes and hepatic tissue damage aredose-dependent processes, and tricyclazole could irreversibly disrupt the metabolic systemof the body
E Fattahi, A Khoskafa,
Volume 17, Issue 8 (8-2015)
Abstract
BACKGROUND AND OBJECTIVE: Oxidative stress is the most common effect of diazinon on living organisms, which leads to the dysfunction and destruction of pancreatic tissues. In this study, we evaluated the effects of Salvia officinalis extracts and optional exercise on histological changes of the pancreas in rats poisoned by diazinon.
METHODS: In this laboratory study, 35 male Wistar rats were divided into five groups, each consisting of seven rats: control, diazinon, diazinon-extract, exercise-extract and exercise-extract-diazinon groups. The exercise groups practiced on a spinning wheel for four weeks. The rats in the experimental groups received 200 mg of diazinon intraperitoneally once during the intervention. In addition, they received 100 mg of the extract for four weeks (five days a week). The rats were sacrificed 24 hours after the final injection. Pancreatic tissue sections were prepared for microscopic studies.
FINDINGS: The number (4.32±0.67) and diameter (15.84±1.01) of the islets of Langerhans and the number of acinar cells (47.32±4.01) in the diazinon group showed a significant reduction, compared to the control group (6.44±1.38, 16.17±1.2 and 50±7.06, respectively) (p<0.05). However, a significant increase was observed in the evaluated parameters in diazinon-extract, exercise-extract and exercise-extract-diazinon groups, compared to the diazinon group (p<0.05).
CONCLUSION: The findings of this study indicated that Salvia officinalis extracts and optional exercise could reduce pancreatic tissue damages, induced by diazinon injection
R Fattahi, A Bahrami,
Volume 20, Issue 0 (Supplement 1-2018 2018)
Abstract
Background: The accumulation of petroleum based plastics, mainly from food packaging, is causing a serious environmental problem. For this reason the efforts of researchers to develop of biodegradable films and coatings increased. The biopolymers used as raw material to prepare edible films should be renewable, abundant and low-cost. This review summarizes the advances starch-based films and coatings for food packaging.
Methods: In this study, scientific articles indexed in databases "Science Direct, Springer, Scopus" were studied using key words "biopolymer, Starch films and Casting method".
Findings: Comparison between mechanical properties of films obtained from starch and stored starch show the effect of recrystallization process to increase rigidity and reduce the flexibility of the resulting film. To prevent this process and its effects on the resulting film can be adding other polymers to the starch matrix. Starch is suitable alternative to petroleum-based polymers. In order to improve the properties of films produced, a great number of compounds can be added to the matrix as well as various changes can be made during processing.
Conclusion: When the conditions are optimized, the gained films are transparent, odorless, tasteless, and colorless, with good mechanical, barrier, and optical properties.
R Fattahi, A Bahrami,
Volume 20, Issue 0 (Supplement 1-2018 2018)
Abstract
Background: Common plastics used in food packaging have a lot of environmental problems. The aim of this study, was to review the latest research results on edible and biodegradable packaging and the positive effect of essential oil in them.
Methods: In order to gather information, articles containing one of the words in their text, including: Food packaging, Edible film, Essential oils and Biodegradable film were searched between 1993 and 2017 in Science direct, Elsevier, Springer, American chemical society (ACS) databases.
Findings: Based on the results of studies, added of essential oils to the biodegradable films caused non-continuous State in the polymer matrix that leads to changes in physical properties such as the weakening the structure, reducing the permeability to water vapor and an increase in turbidity. In addition incorporated of essential oils can cause the creation of antimicrobial and antioxidant characteristics in films.
Conclusion: As compared to conventional emulsion this method is an appropriate route for used in food technology because it can maintain greater of Essential oils in the biopolymer.
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