[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 9 (9-2018) ::
JBUMS 2018, 20(9): 20-27 Back to browse issues page
Association the Study of Between Cpeb1 (Rs230846 C>T) Gene Polymorphism And Azoospermia/ Severe Oligospermia
S Ghorbian , R Kian Bostanabad
2. استادیار، گروه ژنتیک مولکولی، واحد اهر، دانشگاه آزاد اسلامی، اهر، ایران , ghorbian20@yahoo.com
Abstract:   (921 Views)
BACKGROUND AND OBJECTIVE: : CPEB1 gene plays a significant role during gametogenesis. Due to remain unclear many causes of male infertility, we aimed to evaluate the association between of CPEB1 rs2303846 gene polymorphism with the risk of men with idiopathic azoospermia/ severe oligospermia.
METHODS: The present study is a case-control investigation, were performed on 100 peripheral blood samples of men with idiopathic azoospermia/ severe oligozoospermia and 100 blood samples of healthy men, who were referred to department of infertility and sterility of Tabriz Al-Zahra hospital from 2015 to 2017. The PCR-RFLP method was used to determine the frequency of genotypes and then compared the relationship between polymorphism and clinical parameters.
FINDINGS: The genotypes frequency of CEBP1 gene polymorphism CT+TT/CC did not show a statistically significant difference between groups (P=0.395, OR=1.273; CI=0.730-2.220). In addition, no significant correlation was found between genotypes and FSC, MSC and SMI clinical parameters (p<0.05).
CONCLUSION: Findings revealed that CEBP1 rs2303846 gene polymorphism cannot to be considered as a risk factor for idiopathic azoospermia/ severe oligospermia men.

 
Keywords: Azoospermia, Male Infertility, Severe oligospermia
     
Type of Study: Case-Control | Subject: J
Received: 2018/02/4 | Accepted: 2018/07/16 | Published: 2018/07/22
Send email to the article author


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghorbian S, Kian Bostanabad R. Association the Study of Between Cpeb1 (Rs230846 C>T) Gene Polymorphism And Azoospermia/ Severe Oligospermia . JBUMS. 2018; 20 (9) :20-27
URL: http://jbums.org/article-1-7569-en.html


Volume 20, Issue 9 (9-2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Persian site map - English site map - Created in 0.05 seconds with 33 queries by YEKTAWEB 3792