[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 10 (10-2018) ::
JBUMS 2018, 20(10): 0-0 Back to browse issues page
Comparison of the Sedative Effect and Recovery Time of Dexmedetomidine and Fentanyl During Elective Colonoscopy: Double Blind Clinical Trial
Sh Rajaei , P Amri , SH Hamidi , J Shokri , MT Hamidian , K Hajian
Babol University Of Medical Sciences , rohanresearch88@gmail.com
Abstract:   (124 Views)
BACKGROUND AND OBJECTIVE: Various drugs such as propofol or midazolam with or without fentanyl are used for colonoscopy. In this study, we compared the effect of sedative and the recovery time of dexmedetomidine and fentanyl during elective colonoscopy.
METHODS: In a double blind clinical trial, 80 patients (20-70 years) with colonoscopy were randomly divided into two equal groups. In the intervention group, dexmedetomidine was administered 1mcg / kg and in the control group,  fentanyl 0.5 mg / kg before the start of colonoscopy. Propofol (20 mg) was administered as a bolus dose if needed during colonoscopy.
 The sedation score based on the Ramsay sedation scale and the mean bolus dose of propofol was recorded. Recovery time and pain after colonoscopy based on Visual Analog Scale (VAS) was recorded before the discharge.

RESULTS: The two groups did not have a significant difference in age, sex and sedation score (P> 0.05). The mean bolus dose of propofol in the fentanyl group was 72.00 ± 14.00 mg and 7.7 ± 0.24 mg in the dexmedetomidine group (P = 0.000). The recovery time in the fentanyl group was 4.38 ± 2.28 minutes and in the dexmedetomidine group was 2.63 ± 2.21 minutes (P = 0.000). Pain score after colonoscopy (VAS) in the fentanyl group was 2.30 ± 0.99 and in the dexmedetomidine group was 1.98 ± 0.70 (P = 0.039).
CONCLUSION: The combination of dexmedetomidine and propofol is a more appropriate drug than fentanyl and propofol for colonoscopy due to shorter recovery.
Keywords: Propofol, dexmedetomidine, Fentanyl, Clonoscopy, Sedation
     
Type of Study: Interventional | Subject: patology
Received: 2018/02/4 | Accepted: 2018/06/18 | Published: 2018/10/7
Send email to the article author


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rajaei S, Amri P, Hamidi S, Shokri J, Hamidian M, Hajian K. Comparison of the Sedative Effect and Recovery Time of Dexmedetomidine and Fentanyl During Elective Colonoscopy: Double Blind Clinical Trial. JBUMS. 2018; 20 (10)
URL: http://jbums.org/article-1-7568-en.html


Volume 20, Issue 10 (10-2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Persian site map - English site map - Created in 0.06 seconds with 33 queries by YEKTAWEB 3764