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Risk Factors for Significantly Elevated Aminotransferases in Patients with Common Bile Duct Stones Undergoing Endoscopic Retrograde Cholangiopancreatography
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J Shokri Shirvani    , P Akbari Shahabi , H Gholinia , C Behzad * |
| 1.Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, I.R.Iran. , catherinebehzad@yahoo.com |
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Abstract: (28 Views) |
Background and Objective: The presence of elevated aminotransferases, alanine transaminase (ALT) and aspartate transaminase (AST), may be helpful in diagnosis of liver injuries. The significant elevation of aminotransferases is sensitive indicator of liver cell injury. The aminotransferases are usually not greatly elevated in cholestasis and bile duct diseases, one notable exception is acute phase of obstruction of common bile duct (CBD) caused by passage of a stone. Given the limited information in patients with common bile duct stones and significant elevated aminotransferases, the aim of this study was to investigate the risk factors for significantly elevated aminotransferases in patients with common bile duct stones undergoing endoscopic retrograde cholangiopancreatography (ERCP).
Methods: In this cross-sectional study, the clinical and paraclinical findings of 322 patients with common bile duct stones who underwent ERCP in Rouhani Hospital which is the greatest hospital in north of Iran, were evaluated. Patients were devided to case and control groups, those with ALT or AST greater than or equal to 500 were included in the case group and those with ALT or AST levels less than 500 were included in the control group. The two groups were compared in terms of gender, pain, common bile duct diameter, and stone size.
Findings: Of the 322 patients studied, 131 were included in the case group and 191 in the control group. Their mean age was 62.02±13.46 years. Younger age (21.71±22.52), female gender, pain, smaller common bile duct diameter (9.72±6.10), and smaller stone size (33.10±4.37) in the case group were significantly different from the control group (p<0.05).Although these factors independently affected the increase in aminotransferases, we did not find a significant relationship between the effects of these factors together.
Conclusion: The results of this study showed that the risk factors such as younger age, female gender, stone and CBD size is related to significant increase of aminotrasferases. These findings are helpful for better management of these patients for ERCP. |
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| Keywords: Aspartate Transaminase, Alanine Transaminase, ERCP, Common Bile Duct. |
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Type of Study: Cross Sectional |
Subject:
Internal (Digestive)
Received: 2025/06/16 | Accepted: 2025/07/1
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